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International consensus classification of myeloid neoplasms and acute leukemias: integrating morphologic, clinical, and genomic data : special report

The classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for Hematopathology, and the European Association for Haematopathology. This collaboration was primarily based on input from a clinical...

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Main Authors: Arber, Daniel A. (Author) , Orazi, Attilio (Author) , Hasserjian, Robert P. (Author) , Borowitz, Michael J. (Author) , Calvo, Katherine R. (Author) , Kvasnicka, Hans-Michael (Author) , Wang, Sa A. (Author) , Bagg, Adam (Author) , Barbui, Tiziano (Author) , Branford, Susan (Author) , Bueso-Ramos, Carlos E. (Author) , Cortes, Jorge E. (Author) , Dal Cin, Paola (Author) , DiNardo, Courtney D. (Author) , Dombret, Hervé (Author) , Duncavage, Eric J. (Author) , Ebert, Benjamin L. (Author) , Estey, Elihu H. (Author) , Facchetti, Fabio (Author) , Foucar, Kathryn (Author) , Gangat, Naseema (Author) , Gianelli, Umberto (Author) , Godley, Lucy A. (Author) , Gökbuget, Nicola (Author) , Gotlib, Jason (Author) , Hellström-Lindberg, Eva (Author) , Hobbs, Gabriela S. (Author) , Hoffman, Ronald (Author) , Jabbour, Elias J. (Author) , Kiladjian, Jean-Jacques (Author) , Larson, Richard A. (Author) , Le Beau, Michelle M. (Author) , Loh, Mignon L. -C. (Author) , Löwenberg, Bob (Author) , Macintyre, Elizabeth (Author) , Malcovati, Luca (Author) , Mullighan, Charles G. (Author) , Niemeyer, Charlotte (Author) , Odenike, Olatoyosi M. (Author) , Ogawa, Seishi (Author) , Orfao, Alberto (Author) , Papaemmanuil, Elli (Author) , Passamonti, Francesco (Author) , Porkka, Kimmo (Author) , Pui, Ching-Hon (Author) , Radich, Jerald P. (Author) , Reiter, Andreas (Author) , Rozman, Maria (Author) , Rudelius, Martina (Author) , Savona, Michael R. (Author) , Schiffer, Charles A. (Author) , Schmitt-Graeff, Annette (Author) , Shimamura, Akiko (Author) , Sierra, Jorge (Author) , Stock, Wendy A. (Author) , Stone, Richard M. (Author) , Tallman, Martin S. (Author) , Thiele, Jürgen (Author) , Tien, Hwei-Fang (Author) , Tzankov, Alexandar (Author) , Vannucchi, Alessandro M. (Author) , Vyas, Paresh (Author) , Wei, Andrew H. (Author) , Weinberg, Olga K. (Author) , Wierzbowska, Agnieszka (Author) , Cazzola, Mario (Author) , Döhner, Hartmut (Author) , Tefferi, Ayalew (Author)
Format: Article (Journal)
Language:English
Published: 15 September 2022
In: Blood
Year: 2022, Volume: 140, Issue: 11, Pages: 1200-1228
ISSN:1528-0020
DOI:10.1182/blood.2022015850
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.2022015850
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0006497122008369
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Author Notes:Daniel A. Arber, Attilio Orazi, Robert P. Hasserjian, Michael J. Borowitz, Katherine R. Calvo, Hans-Michael Kvasnicka, Sa A. Wang, Adam Bagg, Tiziano Barbui, Susan Branford, Carlos E. Bueso-Ramos, Jorge E. Cortes, Paola Dal Cin, Courtney D. DiNardo, Hervé Dombret, Eric J. Duncavage, Benjamin L. Ebert, Elihu H. Estey, Fabio Facchetti, Kathryn Foucar, Naseema Gangat, Umberto Gianelli, Lucy A. Godley, Nicola Gökbuget, Jason Gotlib, Eva Hellström-Lindberg, Gabriela S. Hobbs, Ronald Hoffman, Elias J. Jabbour, Jean-Jacques Kiladjian, Richard A. Larson, Michelle M. Le Beau, Mignon L.-C. Loh, Bob Löwenberg, Elizabeth Macintyre, Luca Malcovati, Charles G. Mullighan, Charlotte Niemeyer, Olatoyosi M. Odenike, Seishi Ogawa, Alberto Orfao, Elli Papaemmanuil, Francesco Passamonti, Kimmo Porkka, Ching-Hon Pui, Jerald P. Radich, Andreas Reiter, Maria Rozman, Martina Rudelius, Michael R. Savona, Charles A. Schiffer, Annette Schmitt-Graeff, Akiko Shimamura, Jorge Sierra, Wendy A. Stock, Richard M. Stone, Martin S. Tallman, Jürgen Thiele, Hwei-Fang Tien, Alexandar Tzankov, Alessandro M. Vannucchi, Paresh Vyas, Andrew H. Wei, Olga K. Weinberg, Agnieszka Wierzbowska, Mario Cazzola, Hartmut Döhner, and Ayalew Tefferi
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Summary:The classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for Hematopathology, and the European Association for Haematopathology. This collaboration was primarily based on input from a clinical advisory committees (CACs) composed of pathologists, hematologists, oncologists, geneticists, and bioinformaticians from around the world. The recent advances in our understanding of the biology of hematologic malignancies, the experience with the use of the 2016 WHO classification in clinical practice, and the results of clinical trials have indicated the need for further revising and updating the classification. As a continuation of this CAC-based process, the authors, a group with expertise in the clinical, pathologic, and genetic aspects of these disorders, developed the International Consensus Classification (ICC) of myeloid neoplasms and acute leukemias. Using a multiparameter approach, the main objective of the consensus process was the definition of real disease entities, including the introduction of new entities and refined criteria for existing diagnostic categories, based on accumulated data. The ICC is aimed at facilitating diagnosis and prognostication of these neoplasms, improving treatment of affected patients, and allowing the design of innovative clinical trials.
Item Description:Online verfügbar: 1 July 2022, Artikelversion: 15 September 2022
Die Online-Version dieses Artikels enthält eine Datenergänzung
Gesehen am 18.09.2023
Physical Description:Online Resource
ISSN:1528-0020
DOI:10.1182/blood.2022015850

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