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Routinely accessible parameters of mineralocorticoid receptor function, depression subtypes and response prediction: a post-hoc analysis from the early medication change trial in major depressive disorder : original investigations

Objectives Previous studies indicated a relationship between aldosterone, the mineralocorticoid receptor (MR), and antidepressant treatment outcome. Physiological indicators of MR function (blood pressure and electrolytes) are easily accessible and may therefore serve as useful predictors. Thus, our...

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Main Authors: Engelmann, Jan (Author) , Murck, Harald (Author) , Wagner, Stefanie (Author) , Zillich, Lea (Author) , Streit, Fabian (Author) , Herzog, David P. (Author) , Braus, Dieter F. (Author) , Tadic, Andre (Author) , Lieb, Klaus (Author) , Müller, Marianne B. (Author)
Format: Article (Journal)
Language:English
Published: 25 Jan 2022
In: The world journal of biological psychiatry
Year: 2022, Volume: 23, Issue: 8, Pages: 631-642
ISSN:1814-1412
DOI:10.1080/15622975.2021.2020334
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/15622975.2021.2020334
Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/abs/10.1080/15622975.2021.2020334?journalCode=iwbp20
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Author Notes:Jan Engelmann, Harald Murck, Stefanie Wagner, Lea Zillich, Fabian Streit, David P. Herzog, Dieter F. Braus, Andre Tadic, Klaus Lieb and Marianne B. Műller
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Summary:Objectives Previous studies indicated a relationship between aldosterone, the mineralocorticoid receptor (MR), and antidepressant treatment outcome. Physiological indicators of MR function (blood pressure and electrolytes) are easily accessible and may therefore serve as useful predictors. Thus, our aim was to investigate the predictive value of peripheral MR-related markers for antidepressant treatment outcomes.Methods 826 MDD patients who had participated in the randomised-controlled Early Medication Change (EMC) trial were analysed. Depression severity and MR-related markers were assessed weekly. In 562 patients, genetic variation of five MR-related genes was determined.Results Patients with blood pressure <120mmHg showed higher depression severity (p = 0.005) than patients with blood pressure ≥120mmHg. Patients with a melancholic subtype had significantly lower blood pressures (p = 0.004). Na+/K+ ratio was positively and K+-concentration was negatively correlated to depression severity and to relative changes in HAMD from baseline to day 14, and 56 respectively (p < 0.001). For none of the MR-related genes, genetic variation was associated with treatment outcomes.Conclusions We confirmed early observations of an altered peripheral MR sensitivity, reflected by lower blood pressure, low K+ or high Na+/K+ ratio in patients with more severe depression. These routinely collected biomarkers may potentially be useful for risk stratification in an early stage of treatment. Trial Registration: clinicaltrials.gov Identifier: NCT00974155; https://www.clinicaltrials.gov/ct2/results?term=NCT00974155
Item Description:Gesehen am 18.09.2023
Physical Description:Online Resource
ISSN:1814-1412
DOI:10.1080/15622975.2021.2020334

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