Stochastic simulation of calcium microdomains in the vicinity of an L-type calcium channel
We study numerically the local dynamics of the intracellular calcium concentration in the vicinity of a voltage- and calcium-dependent plasma membrane L-type calcium channel. To account for the low number of Ca2+ ions and buffer molecules present in sub-femtoliter volumes, we use an exact stochastic...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2010
|
| In: |
European biophysics journal
Year: 2010, Volume: 39, Issue: 7, Pages: 1079-1088 |
| ISSN: | 1432-1017 |
| DOI: | 10.1007/s00249-009-0504-3 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00249-009-0504-3 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00249-009-0504-3 
|
| Author Notes: | Frederic von Wegner, R.H.A. Fink |
| Summary: | We study numerically the local dynamics of the intracellular calcium concentration in the vicinity of a voltage- and calcium-dependent plasma membrane L-type calcium channel. To account for the low number of Ca2+ ions and buffer molecules present in sub-femtoliter volumes, we use an exact stochastic simulation algorithm including diffusion. We present a novel, unified simulation method that implements reaction-diffusion events of Ca2+ ions and buffer molecules, stochastic ion channel gating and channel conductance as a multivariate Markov process... |
|---|---|
| Item Description: | Online veröffentlicht am 1. Juli 2009 Gesehen am 19.09.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1432-1017 |
| DOI: | 10.1007/s00249-009-0504-3 |