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Rapid antigen tests for SARS-CoV-2: a synopsis of the medical evidence

SARS-CoV-2, the causative agent of the COVID-19 pandemic, continues to influence health, economy, and stability worldwide. Diagnostic testing for SARS-CoV-2 is important to contain the COVID-19 pandemic. With the commercial availability of certified antigen (Ag) rapid diagnostic tests (RDTs), which...

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Bibliographic Details
Main Authors: Wertenauer, Christoph (Author) , Pfeifer, Caroline (Author) , Roskos, Martin (Author) , März, Winfried (Author)
Format: Article (Journal)
Language:English
Published: October 2023
In: Diagnostic microbiology and infectious disease
Year: 2023, Volume: 107, Issue: 2, Pages: 1-6
ISSN:1879-0070
DOI:10.1016/j.diagmicrobio.2023.116027
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.diagmicrobio.2023.116027
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0732889323001372
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Author Notes:Christoph Wertenauer, Caroline Pfeifer, Martin Roskos, Winfried März
Description
Summary:SARS-CoV-2, the causative agent of the COVID-19 pandemic, continues to influence health, economy, and stability worldwide. Diagnostic testing for SARS-CoV-2 is important to contain the COVID-19 pandemic. With the commercial availability of certified antigen (Ag) rapid diagnostic tests (RDTs), which can be used to identify an infection with SARS-CoV-2 an easy-to-use tool was introduced. Self-tests can offer advantages to complement professionally administered rapid antigen detection or nucleic acid amplification testing (NAAT). Compared to real-time polymerase chain reaction (RT-PCR), Ag-RDTs are cost inexpensive, do not need specialized laboratory equipment, facilitating high-throughput testing. However, Ag-RDT sensitivities are strongly dependent on the viral load within the specimen, which has limited their application in clinical settings so far. The methodical limitations of Ag-RDTs may produce false negative test results, particularly when specimens with low viral loads are examined. This may facilitate viral transmissions if protective measurements are lifted mistakenly.
Item Description:Online veröffentlicht am 14. Juli 2023, Artikelversion vom 27. Juli 2023
Gesehen am 20.12.2023
Physical Description:Online Resource
ISSN:1879-0070
DOI:10.1016/j.diagmicrobio.2023.116027

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