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Sudden death of an immunocompetent young adult caused by novel (swine origin) influenza A/H1N1-associated myocarditis

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The main cause of death from novel (swine origin) influenza A/H1N1 infection is acute respiratory distress syndrome. Most fatal cases are immunocompromised patients or patients with a severe underlying disease. Here, we report a fatal case of acute interstitial myocarditis associated with novel infl...

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Main Authors: Gdynia, Georg (Author) , Schnitzler, Paul (Author) , Brunner, Eva (Author) , Kandolf, Reinhard (Author) , Bläker, Hendrik (Author) , Daum, Edith (Author) , Schnabel, Philipp Albert (Author) , Schirmacher, Peter (Author) , Roth, Wilfried (Author)
Format: Article (Journal)
Language:English
Published: 14 January 2011
In: Virchows Archiv
Year: 2011, Volume: 458, Issue: 3, Pages: 371-376
ISSN:1432-2307
DOI:10.1007/s00428-010-1035-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00428-010-1035-0
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Author Notes:Georg Gdynia, Paul Schnitzler, Eva Brunner, Reinhard Kandolf, Hendrik Bläker, Edith Daum, Philipp Schnabel, Peter Schirmacher, Wilfried Roth
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Summary:The main cause of death from novel (swine origin) influenza A/H1N1 infection is acute respiratory distress syndrome. Most fatal cases are immunocompromised patients or patients with a severe underlying disease. Here, we report a fatal case of acute interstitial myocarditis associated with novel influenza A/H1N1 infection in an immunocompetent young woman. A previously healthy 18-year-old woman experienced malaise, diarrhea, and fever for several days prior to a sudden collapse at home. Autopsy revealed a predominantly lymphocytic myocarditis in the absence of a significant respiratory tract infection. Infection with novel (swine origin) influenza A/H1N1 was confirmed by PCR analysis of blood as well as myocardial tissue. Influenza-caused diarrhea with consecutive hypokalemia potentially contributed to the fatal outcome of the myocarditis, characterized by ventricular fibrillation. In conclusion, sudden death by myocarditis may be a rare complication of novel influenza A/H1N1 infection in otherwise healthy individuals, even in the absence of significant respiratory tract infection.
Item Description:Gesehen am 21.09.2023
Physical Description:Online Resource
ISSN:1432-2307
DOI:10.1007/s00428-010-1035-0

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