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Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity

Polymorphonuclear neutrophils (PMNs) of patients with active Wegener's granulomatosis and PMN activated in vitro express elastase on their surface as detected by autoantibodies derived from patients with ANCA- positive vasculitis or chronic staphylococcus infections. The PMN- associated elastas...

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Main Authors: Morcos, Michael (Author) , Zimmermann, F. (Author) , Radsak, Markus Philipp (Author) , Wörner, Inga (Author) , Kramer, Michael D. (Author) , Roland, J. (Author) , Hänsch, Gertrud Maria (Author) , Andrassy, Konrad (Author)
Format: Article (Journal)
Language:English
Published: 1998
In: American journal of kidney diseases
Year: 1998, Volume: 31, Issue: 6, Pages: 978-985
ISSN:1523-6838
DOI:10.1053/ajkd.1998.v31.pm9631842
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1053/ajkd.1998.v31.pm9631842
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0272638698001486
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Author Notes:M Morcos, F Zimmermann, M Radsak, I Worner, MD Kramer, J Roland, GM Hansch, K Andrassy
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Summary:Polymorphonuclear neutrophils (PMNs) of patients with active Wegener's granulomatosis and PMN activated in vitro express elastase on their surface as detected by autoantibodies derived from patients with ANCA- positive vasculitis or chronic staphylococcus infections. The PMN- associated elastase was enzymatically active. By affinity-purified autoantibodies to elastase, the enzymatic activity was further enhanced as measured either by a chromogenic peptide or by elastin as substrate. Antibodies to human elastase from mouse or from sheep also enhanced elastase activity, whereas unrelated immunoglobulins had no effect. Taken together, our data indicate that autoantibodies to elastase are not inhibitory but upregulate the elastase activity and thereby might contribute to tissue damage. (Am J Kidney Dis 1998 Jun;31(6):978-85)
Item Description:Elektronische Reproduktion der Druck-Ausgabe 21. Februar 2008
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Physical Description:Online Resource
ISSN:1523-6838
DOI:10.1053/ajkd.1998.v31.pm9631842

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