Buchumschlag

Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity

Polymorphonuclear neutrophils (PMNs) of patients with active Wegener's granulomatosis and PMN activated in vitro express elastase on their surface as detected by autoantibodies derived from patients with ANCA- positive vasculitis or chronic staphylococcus infections. The PMN- associated elastas...

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Bibliographische Detailangaben
Hauptverfasser: Morcos, Michael (VerfasserIn) , Zimmermann, F. (VerfasserIn) , Radsak, Markus Philipp (VerfasserIn) , Wörner, Inga (VerfasserIn) , Kramer, Michael D. (VerfasserIn) , Roland, J. (VerfasserIn) , Hänsch, Gertrud Maria (VerfasserIn) , Andrassy, Konrad (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1998
In: American journal of kidney diseases
Year: 1998, Jahrgang: 31, Heft: 6, Pages: 978-985
ISSN:1523-6838
DOI:10.1053/ajkd.1998.v31.pm9631842
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1053/ajkd.1998.v31.pm9631842
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0272638698001486
Volltext
Verfasserangaben:M Morcos, F Zimmermann, M Radsak, I Worner, MD Kramer, J Roland, GM Hansch, K Andrassy
Beschreibung
Zusammenfassung:Polymorphonuclear neutrophils (PMNs) of patients with active Wegener's granulomatosis and PMN activated in vitro express elastase on their surface as detected by autoantibodies derived from patients with ANCA- positive vasculitis or chronic staphylococcus infections. The PMN- associated elastase was enzymatically active. By affinity-purified autoantibodies to elastase, the enzymatic activity was further enhanced as measured either by a chromogenic peptide or by elastin as substrate. Antibodies to human elastase from mouse or from sheep also enhanced elastase activity, whereas unrelated immunoglobulins had no effect. Taken together, our data indicate that autoantibodies to elastase are not inhibitory but upregulate the elastase activity and thereby might contribute to tissue damage. (Am J Kidney Dis 1998 Jun;31(6):978-85)
Beschreibung:Elektronische Reproduktion der Druck-Ausgabe 21. Februar 2008
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Beschreibung:Online Resource
ISSN:1523-6838
DOI:10.1053/ajkd.1998.v31.pm9631842

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