Different facets of aging in human mesenchymal stem cells
Mesenchymal stem cells (MSCs) have to be culture expanded to gain relevant cell numbers for therapeutic applications. However, within 2–3 months the proliferation rate of MSCs decays until they ultimately reach a senescent state. This is accompanied by enlarged morphology, reduced expression of surf...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 2, 2010
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| In: |
Tissue engineering. Part B, Reviews
Year: 2010, Volume: 16, Issue: 4, Pages: 445-453 |
| ISSN: | 1937-3376 |
| DOI: | 10.1089/ten.teb.2009.0825 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1089/ten.teb.2009.0825 Verlag, lizenzpflichtig, Volltext: https://www.liebertpub.com/doi/10.1089/ten.teb.2009.0825 
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| Author Notes: | Wolfgang Wagner, Anthony D. Ho, and Martin Zenke |
| Summary: | Mesenchymal stem cells (MSCs) have to be culture expanded to gain relevant cell numbers for therapeutic applications. However, within 2–3 months the proliferation rate of MSCs decays until they ultimately reach a senescent state. This is accompanied by enlarged morphology, reduced expression of surface markers, and decreased differentiation potential. ... |
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| Physical Description: | Online Resource |
| ISSN: | 1937-3376 |
| DOI: | 10.1089/ten.teb.2009.0825 |