Self-assembled liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug-delivery
Liposome-loaded microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. In this paper we design liposome-loaded (lipid-shelled) microbubbles through the simple self-assembly of the involved compounds in a single step process. We thoroughl...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 February 2011
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| In: |
Journal of controlled release
Year: 2011, Volume: 152, Issue: 2, Pages: 249-256 |
| ISSN: | 1873-4995 |
| DOI: | 10.1016/j.jconrel.2011.02.024 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jconrel.2011.02.024 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S016836591100109X 
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| Author Notes: | Bart Geers, Ine Lentacker, Niek N. Sanders, Joseph Demeester, Stephen Meairs, Stefaan C. De Smedt |
| Summary: | Liposome-loaded microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. In this paper we design liposome-loaded (lipid-shelled) microbubbles through the simple self-assembly of the involved compounds in a single step process. We thoroughly characterized the liposome-loading of the microbubbles and evaluated the cell killing efficiency of this material using doxorubicin (DOX) as a model drug. Importantly, we observed that the DOX liposome-loaded microbubbles allowed killing of melanoma cells even at very low doses of DOX. These findings clearly prove the potential of liposome-loaded microbubbles for ultrasound targeted drug delivery to cancer tissues. |
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| Item Description: | Gesehen am 28.09.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1873-4995 |
| DOI: | 10.1016/j.jconrel.2011.02.024 |