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Physiological response to pain in female adolescents with nonsuicidal self-injury as a function of severity

Background - Preliminary evidence indicates altered hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS) response to experimental pain in individuals with nonsuicidal self-injury (NSSI). This study investigated effects of NSSI severity and severity of psychopathology on the H...

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Main Authors: Venne, Patrice van der (Author) , Mürner-Lavanchy, Ines M. (Author) , Höper, Saskia (Author) , Koenig, Julian (Author) , Kaess, Michael (Author)
Format: Article (Journal)
Language:English
Published: 15 October 2023
In: Journal of affective disorders
Year: 2023, Volume: 339, Pages: 64-73
ISSN:1573-2517
DOI:10.1016/j.jad.2023.06.041
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jad.2023.06.041
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0165032723008078
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Author Notes:Patrice van der Venne, Ines Mürner-Lavanchy, Saskia Höper, Julian Koenig, Michael Kaess
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Summary:Background - Preliminary evidence indicates altered hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS) response to experimental pain in individuals with nonsuicidal self-injury (NSSI). This study investigated effects of NSSI severity and severity of psychopathology on the HPA axis and ANS response to pain. - Methods - N = 164 adolescents with NSSI and n = 45 healthy controls received heat pain stimulation. Salivary cortisol, α-amylase and blood pressure were repeatedly assessed before and after painful stimulation. Heart rate (HR) and heart rate variability (HRV) were assessed continuously. NSSI severity and comorbid psychopathology were derived from diagnostic assessments. Main and interaction effects of time of measurement and NSSI severity, adjusted for severity of adverse childhood experiences, borderline personality disorder and depression, on HPA axis and ANS response to pain were examined using regression analyses. - Results - Increasing NSSI severity predicted an increasing cortisol response (χ2(3) = 12.09, p = .007) to pain. After adjusting for comorbid psychopathology, greater NSSI severity predicted decreased α-amylase levels following pain (χ2(3) = 10.47, p = .015), and decreased HR (χ2(2) = 8.53, p = .014) and increased HRV(χ2(2) = 13.43, p = .001) response to pain. - Limitations - Future research should implement several NSSI severity indicators, potentially revealing complex associations with the physiological response to pain. Assessing physiological responses to pain in NSSI in a naturalistic setting presents a promising avenue for future research in NSI. - Conclusions - Findings indicate an increased pain-related HPA axis response and an ANS response characterized by reduced sympathetic and increased parasympathetic activity associated with NSSI severity. Results support claims for dimensional approaches to NSSI and its related psychopathology alongside shared, underlying neurobiological correlates.
Item Description:Online verfügbar: 29. Juni 2023, Artikelversion: 9. Juli 2023
Gesehen am 28.08.2023
Physical Description:Online Resource
ISSN:1573-2517
DOI:10.1016/j.jad.2023.06.041

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