IGSF3-mediated potassium dysregulation promotes neuronal hyperexcitability and glioma progression
Glioblastomas are incurable tumors often associated with epileptic seizures. In a recent study published in Neuron, Curry et al. demonstrated a novel function of the membrane protein IGSF3 that induces potassium dysregulation, neuronal hyperexcitability, and tumor progression. This work uncovers a n...
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 2023
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| In: |
Trends in cancer
Year: 2023, Volume: 9, Issue: 6, Pages: 457-458 |
| ISSN: | 2405-8025 |
| DOI: | 10.1016/j.trecan.2023.04.005 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.trecan.2023.04.005 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2405803323000614 
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| Author Notes: | Varun Venkataramani |
| Summary: | Glioblastomas are incurable tumors often associated with epileptic seizures. In a recent study published in Neuron, Curry et al. demonstrated a novel function of the membrane protein IGSF3 that induces potassium dysregulation, neuronal hyperexcitability, and tumor progression. This work uncovers a novel layer of bidirectional neuron-tumor communication, further underlining the importance of comprehensively investigating neuron-tumor networks in glioblastoma. |
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| Item Description: | Online verfügbar: 24. April 2023, Artikelversion: 16. Mai 2023 Gesehen am 02.10.2023 |
| Physical Description: | Online Resource |
| ISSN: | 2405-8025 |
| DOI: | 10.1016/j.trecan.2023.04.005 |