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RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits

Although five 5-hydroxytryptamine type 3 (5-HT3) subunits (A-E) have been cloned, knowledge on the regulation of their assembly is limited. RIC-3 has been identified as a chaperone specific for the pentameric ligand-gated nicotinic acetylcholine and 5-HT3 receptors. Therefore, we examined the impact...

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Bibliographic Details
Main Authors: Walstab, Jutta (Author) , Hammer, Christian (Author) , Lasitschka, Felix (Author) , Möller, Dorothee (Author) , Connolly, Christopher N. (Author) , Rappold, Gudrun (Author) , Brüss, Michael (Author) , Bönisch, Heinz (Author) , Niesler, Beate (Author)
Format: Article (Journal)
Language:English
Published: June 3, 2010
In: The journal of biological chemistry
Year: 2010, Volume: 285, Issue: 35, Pages: 26956-26965
ISSN:1083-351X
DOI:10.1074/jbc.M110.122838
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1074/jbc.M110.122838
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S002192582059488X
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Author Notes:Jutta Walstab, Christian Hammer, Felix Lasitschka, Dorothee Möller, Christopher N. Connolly, Gudrun Rappold, Michael Brüss, Heinz Bönisch, and Beate Niesler
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Summary:Although five 5-hydroxytryptamine type 3 (5-HT3) subunits (A-E) have been cloned, knowledge on the regulation of their assembly is limited. RIC-3 has been identified as a chaperone specific for the pentameric ligand-gated nicotinic acetylcholine and 5-HT3 receptors. Therefore, we examined the impact of RIC-3 on differently composed 5-HT3 receptors with the focus on 5-HT3C, -D, and -E subunits. The influence of RIC-3 on these receptor subtypes is supported by the presence of RIC3 mRNA in tissues expressing at least one of the subunits 5-HT3C, -D, and -E. Furthermore, immunocytochemical studies on transfected mammalian cells revealed co-localization in the endoplasmic reticulum and direct interaction of RIC-3 with 5-HT3A, -C, -D, and -E. F ...
Item Description:Im Titel erscheint bei dem Ausdruck (5-HT3A) die Ziffer 3 tiefgestellt
Gesehen am 04.10.2023
Physical Description:Online Resource
ISSN:1083-351X
DOI:10.1074/jbc.M110.122838

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