A shea butter-based ketamine ointment: the antidepressant effects of transdermal ketamine in rats
The delayed onset of monoaminergic antidepressants and disadvantages of traditional administration routes created the need for alternative non-invasive delivery methods with rapid onset therapeutic effect. Ketamine attracted attention as a fast-acting glutamatergic antidepressant with ideal physioch...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2023
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| In: |
Behavioural brain research
Year: 2023, Volume: 452, Pages: 1-5 |
| ISSN: | 1872-7549 |
| DOI: | 10.1016/j.bbr.2023.114594 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://dx.doi.org/10.1016/j.bbr.2023.114594 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0166432823003121 
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| Author Notes: | Merve Akan, Ivan Skorodumov, Marcus W. Meinhardt, Resit Canbeyli, Gunes Unal |
| Summary: | The delayed onset of monoaminergic antidepressants and disadvantages of traditional administration routes created the need for alternative non-invasive delivery methods with rapid onset therapeutic effect. Ketamine attracted attention as a fast-acting glutamatergic antidepressant with ideal physiochemical properties for alternative routes of administration. However, there is no sufficient data for its transdermal use in depression. In this proof-of-concept study, we investigated the antidepressant effects of transdermal ketamine delivered via a novel ointment with skin protective, emulsifying and permeation enhancing properties. A shea butter-based 5% (w/w) ketamine ointment or a drug-free vehicle ointment were applied to the shaved dorsal skin of male Wistar rats for 2 days, twice a day. Behavioral despair, locomotor activity and anxiety-like behavior were respectively assessed in the forced swim test (FST), open field test (OFT), and elevated plus maze (EPM). The pharmacokinetic profile of the ointment was analyzed with high-performance liquid chromatography. Transdermal ketamine ameliorated behavioral despair without altering general locomotor activity and anxiety-like behavior, showing that skin-friendly drug carriers like shea butter may constitute promising alternatives to current routes of delivery for ketamine. Tested transdermal method aims to provide more sustainable drug delivery for long-term treatment schedules. Future studies can investigate its long-term use, side effects and abuse liability. |
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| Item Description: | Online verfügbar 23 July 2023, Artikelversion 25 July 2023 Gesehen am 04.10.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7549 |
| DOI: | 10.1016/j.bbr.2023.114594 |