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Surgical treatment of carcinomas of the oral minor salivary glands - oncological outcome in dependence of tumor entity and therapeutic strategies

The aim of this study was to analyze the clinical outcomes of three types of minor salivary gland carcinomas (adenoid-cystic carcinomas (ACC), adeno carcinomas not otherwise specified (AC-NOS), and mucoepidermoid carcinomas (MEC)) after primary surgical therapy. A retrospective cohort study was desi...

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Main Authors: Moratin, Julius (Author) , Horn, Dominik (Author) , Semmelmayer, Karl (Author) , Ristow, Oliver (Author) , Engel, Michael (Author) , Hoffmann, Jürgen (Author) , Bleymehl, Moritz (Author) , Held, Thomas (Author) , Zittel, Sven (Author) , Freudlsperger, Christian (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Cancers
Year: 2023, Volume: 15, Issue: 15, Pages: 1-14
ISSN:2072-6694
DOI:10.3390/cancers15153895
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers15153895
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/15/15/3895
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Author Notes:Julius Moratin, Dominik Horn, Karl Semmelmayer, Oliver Ristow, Michael Engel, Jürgen Hoffmann, Moritz Bleymehl, Thomas Held, Sven Zittel and Christian Freudlsperger
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Summary:The aim of this study was to analyze the clinical outcomes of three types of minor salivary gland carcinomas (adenoid-cystic carcinomas (ACC), adeno carcinomas not otherwise specified (AC-NOS), and mucoepidermoid carcinomas (MEC)) after primary surgical therapy. A retrospective cohort study was designed and patients with cancer of the minor oral salivary glands treated in our department in the years 2011 to 2022 were included. Clinicopathological data were evaluated to compare overall survival and progression-free survival between the entities. Eighty-one patients were included. The rates of cervical metastases were 38.9% for ACC, 25% for MEC, and 9.1% for AC-NOS. ACC exhibited significantly higher rates of local and systemic disease recurrence (p = 0.02), and the presence of neck node metastases was confirmed as an independent prognostic factor for progression-free survival (p = 0.014). Treatment success in terms of oncological outcome varied significantly between the different entities and implies different treatment regimens for each tumor entity.
Item Description:Veröffentlicht: 31. Juli 2023
Gesehen am 04.10.2023
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers15153895

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