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ARID1A mutations in lung cancer: biology, prognostic role, and therapeutic implications

Mutations in the AT-interacting domain-rich protein 1A (ARID1A) gene, a critical component of the switch/sucrose nonfermentable (SWI/SNF) complex, are frequently found in most human cancers. Approximately 5-10% of lung cancers carry ARID1A mutations. ARID1A loss in lung cancer correlates with clinic...

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Main Authors: Jin, Fukang (Author) , Yang, Zhiguang (Author) , Shao, Jingbo (Author) , Tao, Jianxin (Author) , Reißfelder, Christoph (Author) , Loges, Sonja (Author) , Zhu, Lei (Author) , Schölch, Sebastian (Author)
Format: Article (Journal)
Language:English
Published: 11 May 2023
In: Trends in molecular medicine
Year: 2023, Volume: 29, Issue: 8, Pages: 646-658
ISSN:1471-499X
DOI:10.1016/j.molmed.2023.04.005
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molmed.2023.04.005
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1471491423000758
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Author Notes:Fukang Jin, Zhiguang Yang, Jingbo Shao, Jianxin Tao, Christoph Reißfelder, Sonja Loges, Lei Zhu and Sebastian Schölch
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Summary:Mutations in the AT-interacting domain-rich protein 1A (ARID1A) gene, a critical component of the switch/sucrose nonfermentable (SWI/SNF) complex, are frequently found in most human cancers. Approximately 5-10% of lung cancers carry ARID1A mutations. ARID1A loss in lung cancer correlates with clinicopathological features and poor prognosis. Co-mutation of ARID1A and epidermal growth factor receptor (EGFR) results in the limited efficacy of EGFR tyrosine kinase inhibitors (EGFR-TKIs) but increases the clinical benefit of immune checkpoint inhibitors (ICIs). ARID1A gene mutation plays a role in cell cycle regulation, metabolic reprogramming, and epithelial-mesenchymal transition. We present the first comprehensive review of the relationship between ARID1A gene mutations and lung cancer and discuss the potential of ARID1A as a new molecular target.
Item Description:Online verfügbar 11 May 202323
Gesehen am 05.10.2023
Physical Description:Online Resource
ISSN:1471-499X
DOI:10.1016/j.molmed.2023.04.005

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