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Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury

We previously showed that loss of yes-associated protein 1 (YAP) in early liver development (YAPKO) leads to an Alagille syndrome-like phenotype, with failure of intrahepatic bile duct development, severe cholestasis, and chronic hepatocyte adaptations to reduce liver injury. TAZ, a paralog of YAP,...

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Main Authors: Gabdulkhakova, Adelya (Author) , Krutsenko, Yekaterina (Author) , Zhu, Junjie (Author) , Liu, Silvia (Author) , Poddar, Minakshi (Author) , Singh, Sucha (Author) , Ma, Xiaochao (Author) , Nejak-Bowen, Kari (Author) , Monga, Satdarshan P.S. (Author) , Molina-Molina, Laura (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Hepatology communications
Year: 2023, Volume: 7, Issue: 9, Pages: 1-13
ISSN:2471-254X
DOI:10.1097/HC9.0000000000000220
Online Access:Verlag, kostenfrei, Volltext: https://dx.doi.org/10.1097/HC9.0000000000000220
Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412434/
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Author Notes:Adelya Gabdulkhakova, Yekaterina Krutsenko, Junjie Zhu, Silvia Liu, Minakshi Poddar, Sucha Singh, Xiaochao Ma, Kari Nejak-Bowen, Satdarshan P.S. Monga, Laura M. Molina
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Summary:We previously showed that loss of yes-associated protein 1 (YAP) in early liver development (YAPKO) leads to an Alagille syndrome-like phenotype, with failure of intrahepatic bile duct development, severe cholestasis, and chronic hepatocyte adaptations to reduce liver injury. TAZ, a paralog of YAP, was significantly upregulated in YAPKO hepatocytes and interacted with TEA domain family member (TEAD) transcription factors, suggesting possible compensatory activity.,
Item Description:Gesehen am 05.10.2023
Physical Description:Online Resource
ISSN:2471-254X
DOI:10.1097/HC9.0000000000000220

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