Buchumschlag

Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury

We previously showed that loss of yes-associated protein 1 (YAP) in early liver development (YAPKO) leads to an Alagille syndrome-like phenotype, with failure of intrahepatic bile duct development, severe cholestasis, and chronic hepatocyte adaptations to reduce liver injury. TAZ, a paralog of YAP,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Gabdulkhakova, Adelya (VerfasserIn) , Krutsenko, Yekaterina (VerfasserIn) , Zhu, Junjie (VerfasserIn) , Liu, Silvia (VerfasserIn) , Poddar, Minakshi (VerfasserIn) , Singh, Sucha (VerfasserIn) , Ma, Xiaochao (VerfasserIn) , Nejak-Bowen, Kari (VerfasserIn) , Monga, Satdarshan P.S. (VerfasserIn) , Molina-Molina, Laura (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2023
In: Hepatology communications
Year: 2023, Jahrgang: 7, Heft: 9, Pages: 1-13
ISSN:2471-254X
DOI:10.1097/HC9.0000000000000220
Online-Zugang:Verlag, kostenfrei, Volltext: https://dx.doi.org/10.1097/HC9.0000000000000220
Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412434/
Volltext
Verfasserangaben:Adelya Gabdulkhakova, Yekaterina Krutsenko, Junjie Zhu, Silvia Liu, Minakshi Poddar, Sucha Singh, Xiaochao Ma, Kari Nejak-Bowen, Satdarshan P.S. Monga, Laura M. Molina
Beschreibung
Zusammenfassung:We previously showed that loss of yes-associated protein 1 (YAP) in early liver development (YAPKO) leads to an Alagille syndrome-like phenotype, with failure of intrahepatic bile duct development, severe cholestasis, and chronic hepatocyte adaptations to reduce liver injury. TAZ, a paralog of YAP, was significantly upregulated in YAPKO hepatocytes and interacted with TEA domain family member (TEAD) transcription factors, suggesting possible compensatory activity.,
Beschreibung:Gesehen am 05.10.2023
Beschreibung:Online Resource
ISSN:2471-254X
DOI:10.1097/HC9.0000000000000220

Ähnliche Einträge