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Precise mapping of subunits in multiprotein complexes by a versatile electron microscopy label

While the topological analysis of protein complexes by electron microscopy (EM) has developed in recent years, the exact position of single subunits within multisubunit complexes has been difficult. A new clonable peptide tag, which when attached to a target protein can recruit a structurally promin...

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Bibliographic Details
Main Authors: Flemming, Dirk (Author) , Thierbach, Karsten (Author) , Stelter, Philipp (Author) , Böttcher, Bettina (Author) , Hurt, Ed (Author)
Format: Article (Journal)
Language:English
Published: 30 May 2010
In: Nature structural & molecular biology
Year: 2010, Volume: 17, Issue: 6, Pages: 775-778
ISSN:1545-9985
DOI:10.1038/nsmb.1811
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nsmb.1811
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nsmb.1811
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Author Notes:Dirk Flemming, Karsten Thierbach, Philipp Stelter, Bettina Böttcher & Ed Hurt
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Summary:While the topological analysis of protein complexes by electron microscopy (EM) has developed in recent years, the exact position of single subunits within multisubunit complexes has been difficult. A new clonable peptide tag, which when attached to a target protein can recruit a structurally prominent label that is easily identifiable by EM, may help solve this problem.
Item Description:Gesehen am 09.10.2023
Physical Description:Online Resource
ISSN:1545-9985
DOI:10.1038/nsmb.1811

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