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Everolimus in patients with autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) affects approximately 1 of every 1000 persons in the general population1 and develops, by means of slowly progressive renal-cyst growth, to end-stage renal disease in over 50% of patients. Hepatic and pancreatic cysts, as well as cerebral and abdo...

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Main Authors: Walz, Gerd (Author) , Budde, Klemens (Author) , Mannaa, Marwan (Author) , Nürnberger, Jens (Author) , Wanner, Christoph (Author) , Sommerer, Claudia (Author) , Kunzendorf, Ulrich (Author) , Banas, Bernhard (Author) , Hörl, Walter H. (Author) , Obermüller, Nicholas (Author) , Arns, Wolfgang (Author) , Pavenstädt, Hermann (Author) , Gaedeke, Jens (Author) , Büchert, Martin (Author) , May, Christoph (Author) , Gschaidmeier, Harald (Author) , Kramer, Stefan (Author) , Eckardt, Kai-Uwe (Author)
Format: Article (Journal)
Language:English
Published: June 26, 2010
In: The New England journal of medicine
Year: 2010, Volume: 363, Issue: 9, Pages: 830-840
ISSN:1533-4406
DOI:10.1056/NEJMoa1003491
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa1003491
Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa1003491
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Author Notes:Gerd Walz, Klemens Budde, Marwan Mannaa, Jens Nürnberger, Christoph Wanner, Claudia Sommerer, Ulrich Kunzendorf, Bernhard Banas, Walter H. Hörl, Nicholas Obermüller, Wolfgang Arns, Hermann Pavenstädt, Jens Gaedeke, Martin Büchert, Christoph May, Harald Gschaidmeier, Stefan Kramer, and Kai-Uwe Eckardt
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Summary:Autosomal dominant polycystic kidney disease (ADPKD) affects approximately 1 of every 1000 persons in the general population1 and develops, by means of slowly progressive renal-cyst growth, to end-stage renal disease in over 50% of patients. Hepatic and pancreatic cysts, as well as cerebral and abdominal aneurysms, contribute to ADPKD-associated morbidity and mortality. Arterial hypertension, recurrent urinary tract infection, nephrolithiasis, and abdominal pain are frequently the presenting symptoms.2 Approximately 85% of patients with ADPKD have mutations in the polycystic kidney disease 1 gene (PKD1), whereas most of the remaining 15% have polycystic kidney disease 2 gene (PKD2) . . .
Item Description:Gesehen am 10.10.2023
Physical Description:Online Resource
ISSN:1533-4406
DOI:10.1056/NEJMoa1003491

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