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Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling

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Toll-like receptors (TLRs) recognize specific molecular patterns derived from microbial components (exogenous ligands) or stressed cells (endogenous ligands). Stimulation of these receptors leads to a pronounced inflammatory response in a variety of acute animal models. Chronic allograft dysfunction...

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Main Authors: Wang, Shijun (Author) , Schmaderer, Christoph (Author) , Kiss, Eva (Author) , Schmidt, Claudia (Author) , Bonrouhi, Mahnaz (Author) , Porubský, Štefan (Author) , Gretz, Norbert (Author) , Schäfer, Liliana (Author) , Kirschning, Carsten Jürgen (Author) , Popovic, Zoran V. (Author) , Gröne, Hermann-Josef (Author)
Format: Article (Journal)
Language:English
Published: 14 January 2010
In: Disease models & mechanisms
Year: 2010, Volume: 3, Issue: 1/2, Pages: 92-103
ISSN:1754-8411
DOI:10.1242/dmm.003533
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1242/dmm.003533
Verlag, lizenzpflichtig, Volltext: https://journals.biologists.com/dmm/article/3/1-2/92/2409/Recipient-Toll-like-receptors-contribute-to
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Author Notes:Shijun Wang, Christoph Schmaderer, Eva Kiss, Claudia Schmidt, Mahnaz Bonrouhi, Stefan Porubsky, Norbert Gretz, Liliana Schaefer, Carsten J. Kirschning, Zoran V. Popovic and Hermann-Josef Gröne
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Summary:Toll-like receptors (TLRs) recognize specific molecular patterns derived from microbial components (exogenous ligands) or stressed cells (endogenous ligands). Stimulation of these receptors leads to a pronounced inflammatory response in a variety of acute animal models. Chronic allograft dysfunction (CAD) was regarded as a candidate disease to test whether TLRs influence chronic fibrosing inflammation....
Item Description:Gesehen am 10.10.2023
Physical Description:Online Resource
ISSN:1754-8411
DOI:10.1242/dmm.003533

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