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Longitudinal sudy of intestinal symptoms and fecal continence in patients with conformal radiotherapy for prostate cancer

Purpose - To prospectively assess the intestinal symptoms and fecal continence in patients who had undergone conformal radiotherapy (CRT) for prostate cancer. - Methods and Materials - A total of 78 men who had undergone definitive CRT for prostate cancer were evaluated. The patients were assessed b...

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Main Authors: Geinitz, Hans (Author) , Thamm, Reinhard (Author) , Keller, Monika (Author) , Astner, Sabrina T. (Author) , Heinrich, Christine (Author) , Scholz, Christian (Author) , Pehl, Christian (Author) , Kerndl, Simone (Author) , Prause, Nina (Author) , Busch, Raymonde (Author) , Molls, Michael (Author) , Zimmermann, Frank B. (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: International journal of radiation oncology, biology, physics
Year: 2011, Volume: 79, Issue: 5, Pages: 1373-1380
ISSN:1879-355X
DOI:10.1016/j.ijrobp.2010.01.033
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2010.01.033
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0360301610001331
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Author Notes:Hans Geinitz, M.D., Reinhard Thamm, M.D., Monika Keller, M.D., Sabrina T. Astner, M.D., Christine Heinrich, M.D., Christian Scholz, Christian Pehl, M.D., Simone Kerndl, Nina Prause, Raymonde Busch, M.Sc., Michael Molls, M.D., and Frank B. Zimmermann, M.D.
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Summary:Purpose - To prospectively assess the intestinal symptoms and fecal continence in patients who had undergone conformal radiotherapy (CRT) for prostate cancer. - Methods and Materials - A total of 78 men who had undergone definitive CRT for prostate cancer were evaluated. The patients were assessed before, during (treatment Weeks 4 and 6), and 2, 12, and 24 months after CRT completion. The intestinal symptoms and fecal continence were evaluated with comprehensive standardized questionnaires. - Results - The intestinal symptoms were mostly intermittent, with only a small minority of patients affected daily. Defecation pain, fecal urge, and rectal mucous discharge increased significantly during therapy. Defecation pain and rectal mucous discharge had returned to baseline levels within 8 weeks and 1 year after CRT, respectively. However, fecal urge remained significantly elevated for ≤1 year and then returned toward the pretreatment values. The prevalence of rectal bleeding was significantly elevated 2 years after CRT. Fecal continence deteriorated during CRT and remained impaired at 1 year after treatment. Incontinence was mostly minor, occurring less than once per week and predominantly affecting incontinence for gas. - Conclusion - Intestinal symptoms and fecal incontinence increased during prostate CRT. Except for rectal bleeding, the intestinal symptoms, including fecal incontinence, returned to baseline levels within 1-2 years after CRT. Thus, the rate of long-term late radiation-related intestinal toxicity was low.
Item Description:Gesehen am 11.10.2023
Online verfügbar ab 27. Oktober 2010
Physical Description:Online Resource
ISSN:1879-355X
DOI:10.1016/j.ijrobp.2010.01.033

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