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Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism

Increased circulating uric acid (UA) concentration may disrupt cardiac function in heart failure patients, but the specific mechanism remains unclear. Here, we postulate that hyperuremia induces sterol regulatory element binding protein 1 (SREBP1), which in turn activate hepatic fatty acid biosynthe...

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Bibliographic Details
Main Authors: Lou, Bowen (Author) , Wu, Haoyu (Author) , Ott, Hannes (Author) , Bennewitz, Katrin (Author) , Wang, Chen (Author) , Poschet, Gernot (Author) , Liu, Hui (Author) , Yuan, Zuyi (Author) , Kroll, Jens (Author) , She, Jianqing (Author)
Format: Article (Journal)
Language:English
Published: 16 March 2023
In: Journal of translational medicine
Year: 2023, Volume: 21, Pages: 1-15
ISSN:1479-5876
DOI:10.1186/s12967-023-04050-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12967-023-04050-5
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Author Notes:Bowen Lou, Haoyu Wu, Hannes Ott, Katrin Bennewitz, Chen Wang, Gernot Poschet, Hui Liu, Zuyi Yuan, Jens Kroll and Jianqing She
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Summary:Increased circulating uric acid (UA) concentration may disrupt cardiac function in heart failure patients, but the specific mechanism remains unclear. Here, we postulate that hyperuremia induces sterol regulatory element binding protein 1 (SREBP1), which in turn activate hepatic fatty acid biosynthesis response, leading to cardiac dysfunction.
Item Description:Gesehen am 12.10.2023
Physical Description:Online Resource
ISSN:1479-5876
DOI:10.1186/s12967-023-04050-5

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