Comutations and KRASG12C inhibitor efficacy in advanced NSCLC
In this work, we identify co-occurring genomic alterations in KEAP1, SMARCA4, and CDKN2A as independent determinants of poor clinical outcomes with KRASG12Ci monotherapy in advanced NSCLC, and we propose a framework for patient stratification and treatment personalization based on the comutational s...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 29 2023
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| In: |
Cancer discovery
Year: 2023, Volume: 13, Issue: 7, Pages: 1556-1571 |
| ISSN: | 2159-8290 |
| DOI: | 10.1158/2159-8290.CD-22-1420 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/2159-8290.CD-22-1420 Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/cancerdiscovery/article/13/7/1556/727614/Comutations-and-KRASG12C-Inhibitor-Efficacy-in 
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| Author Notes: | Marcelo V. Negrao, Haniel A. Araujo, Giuseppe Lamberti, Alissa J. Cooper, Neal S. Akhave, Teng Zhou, Lukas Delasos, J. Kevin Hicks, Mihaela Aldea, Gabriele Minuti, Jacobi Hines, Jacqueline V. Aredo, Michael J. Dennis, Turja Chakrabarti, Susan C. Scott, Paolo Bironzo, Matthias Scheffler, Petros Christopoulos, Albrecht Stenzinger, Jonathan W. Riess, So Yeon Kim, Sarah B. Goldberg, Mingjia Li, Qi Wang, Yun Qing, Ying Ni, Minh Truong Do, Richard Lee, Biagio Ricciuti, Joao Victor Alessi, Jing Wang, Blerina Resuli, Lorenza Landi, Shu-Chi Tseng, Mizuki Nishino, Subba R. Digumarthy, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, Ara A. Vaporciyan, George R., Jr Blumenschein, Jianjun Zhang, Dwight H. Owen, Collin M. Blakely, Giannis Mountzios, Catherine A. Shu, Christine M. Bestvina, Marina Chiara Garassino, Kristen A. Marrone, Jhanelle E. Gray, Sandip Pravin Patel, Amy L. Cummings, Heather A. Wakelee, Juergen Wolf, Giorgio Vittorio Scagliotti, Federico Cappuzzo, Fabrice Barlesi, Pradnya D. Patil, Leylah Drusbosky, Don L. Gibbons, Funda Meric-Bernstam, J. Jack Lee, John V. Heymach, David S. Hong, Rebecca S. Heist, Mark M. Awad, and Ferdinandos Skoulidis |
| Summary: | In this work, we identify co-occurring genomic alterations in KEAP1, SMARCA4, and CDKN2A as independent determinants of poor clinical outcomes with KRASG12Ci monotherapy in advanced NSCLC, and we propose a framework for patient stratification and treatment personalization based on the comutational status of individual tumors. |
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| Item Description: | Im Titel erscheint die Zeichenfolge "G12C" hochgestellt Gesehen am 15.11.2023 |
| Physical Description: | Online Resource |
| ISSN: | 2159-8290 |
| DOI: | 10.1158/2159-8290.CD-22-1420 |