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Calcimimetic AMG-416 induced short-term changes in calcium concentrations and calcium isotope ratios in rats

Calcium (Ca) isotopes (δ44/42Ca) in serum and urine have been suggested as novel sensitive markers of bone calcification. The response of δ44/42Ca to acute changes in Ca homeostasis, has not yet been demonstrated. We measured serum Ca and δ44/42Ca in rats maintained on a standard and a 50% Ca reduce...

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Main Authors: Rott, Jeremy (Author) , Töpfer, Eva Teresa (Author) , Bartosova, Maria (Author) , Damgov, Ivan (Author) , Kolevica, Ana (Author) , Heuser, Alexander (Author) , Shroff, Rukshana (Author) , Zarogiannis, Sotirios G. (Author) , Eisenhauer, Anton (Author) , Schmitt, Claus P. (Author)
Format: Article (Journal)
Language:English
Published: 15 October 2023
In: Biochemical and biophysical research communications
Year: 2023, Volume: 677, Pages: 88-92
ISSN:1090-2104
DOI:10.1016/j.bbrc.2023.07.060
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bbrc.2023.07.060
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0006291X23009324
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Author Notes:Jeremy Rott, Eva Teresa Töpfer, Maria Bartosova, Ivan Damgov, Ana Kolevica, Alexander Heuser, Rukshana Shroff, Sotirios G. Zarogiannis, Anton Eisenhauer, Claus Peter Schmitt
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Summary:Calcium (Ca) isotopes (δ44/42Ca) in serum and urine have been suggested as novel sensitive markers of bone calcification. The response of δ44/42Ca to acute changes in Ca homeostasis, has not yet been demonstrated. We measured serum Ca and δ44/42Ca in rats maintained on a standard and a 50% Ca reduced diet for 4 weeks, and after injection of 1 mg/kg of the calcimimetic AMG-416, 24 h prior to sacrifice. AMG-416 decreased serum Ca by a maximum of 0.38 ± 0.10 and 0.53 ± 0.35 mmol/l after 12 and 6 h, respectively, in the standard and low-Ca diet groups (p = 0.0006/0.02), while serum δ44/42Ca did not change over 24 h in both groups. Urinary Ca concentrations were higher 24 h after AMG-416 injection in both groups (p = 0.03/0.06), urine δ44/42Ca was not different compared to the untreated control groups. Our data does not show acute changes in δ44/42Ca in response to a single dose of AMG-416 within 24 h after injection, possibly due to a lack of bone calcification.
Item Description:Online verfügbar: 1. August 2023, Artikelversion: 8. August 2023
Gesehen am 18.10.2023
Physical Description:Online Resource
ISSN:1090-2104
DOI:10.1016/j.bbrc.2023.07.060

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