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Activation of PPARγ by pioglitazone does not attenuate left ventricular hypertrophy following aortic banding in rats

Sustained left ventricular hypertrophy (LVH) accelerates cardiac dysfunction and heart failure. Previous reports have suggested that activation of the peroxisome proliferator-activated receptor γ (PPARγ)-dependent pathway is involved in development of cardiac hypertrophy. Thiazolidinediones (TZDs) s...

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Main Authors: Weiss, Celine (Author) , Hagenmüller, Marco (Author) , Pichler, Martina (Author) , Münz, Sebastian Gregor (Author) , Ochs, Marco (Author) , Buß, Sebastian Johannes (Author) , Bekeredjian, Raffi (Author) , Katus, Hugo (Author) , Hardt, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 27 January 2010
In: Naunyn-Schmiedeberg's archives of pharmacology
Year: 2010, Volume: 381, Issue: 4, Pages: 285-295
ISSN:1432-1912
DOI:10.1007/s00210-009-0488-7
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00210-009-0488-7
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00210-009-0488-7
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Author Notes:Celine S. Weiss, Marco Hagenmüller, Martina Pichler, Sebastian Münz, Marco Ochs, Sebastian J. Buss, Raffi Bekeredjian, Hugo A. Katus, Stefan E. Hardt
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Summary:Sustained left ventricular hypertrophy (LVH) accelerates cardiac dysfunction and heart failure. Previous reports have suggested that activation of the peroxisome proliferator-activated receptor γ (PPARγ)-dependent pathway is involved in development of cardiac hypertrophy. Thiazolidinediones (TZDs) such as pioglitazone activate PPARγ and are clinically used as antidiabetics. Given inconsistent reports regarding effects of TZDs on LVH, we examined in the present study the influence of pioglitazone on LVH in a rat model of aortic banding...
Item Description:Gesehen am 19.10.2023
Physical Description:Online Resource
ISSN:1432-1912
DOI:10.1007/s00210-009-0488-7

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