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Impact of age on endothelial function of saphenous vein grafts in coronary artery bypass grafting

Background: An intact and functionally preserved endothelial layer in the graft is crucial for myocardial perfusion and graft patency after coronary artery bypass grafting (CABG). We hypothesized that old age is a risk factor for decreased endothelial function of bypass grafts. Thus, we investigated...

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Main Authors: Saemann, Lars (Author) , Wernstedt, Lena (Author) , Pohl, Sabine (Author) , Stiller, Markus (Author) , Willsch, Jan (Author) , Hofmann, Britt (Author) , Veres, Gábor (Author) , Simm, Andreas (Author) , Szabó, Gábor (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Journal of Clinical Medicine
Year: 2023, Volume: 12, Issue: 17, Pages: 1-17
ISSN:2077-0383
DOI:10.3390/jcm12175454
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/jcm12175454
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2077-0383/12/17/5454
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Author Notes:Lars Saemann, Lena Wernstedt, Sabine Pohl, Markus Stiller, Jan Willsch, Britt Hofmann, Gábor Veres, Andreas Simm and Gábor Szabó
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Summary:Background: An intact and functionally preserved endothelial layer in the graft is crucial for myocardial perfusion and graft patency after coronary artery bypass grafting (CABG). We hypothesized that old age is a risk factor for decreased endothelial function of bypass grafts. Thus, we investigated the impact of age in patients treated with CABG on endothelial function in saphenous vein grafts. Methods: We mounted the saphenous vein graft segments of CABG patients < 70 (n = 33) and ≥70 (n = 40) years of age in organ bath chambers and exposed them to potassium chloride (KCl) and phenylephrine (PE) to test the receptor-independent and -dependent contractility, followed by exposure to acetylcholine (ACh) and sodium nitroprusside (SNP) to test the endothelial-dependent and -independent relaxation. Results: The maximal contraction induced by KCl (2.3 ± 1.8 vs. 1.8 ± 2 g) was stronger in patients ≥ 70 years of age. The relative contraction induced by PE in % of KCl (167 ± 64 vs. 163 ± 59%) was similar between groups. Patients aged < 70 years showed a higher endothelial-dependent relaxation induced by acetylcholine than patients ≥ 70 years (51 ± 27 vs. 42 ± 18%). The relaxation induced by SNP was similar between both groups. Conclusions: The endothelial function of saphenous vein bypass grafts decreases during aging. Thus, age should be considered when improving graft maintenance.
Item Description:Veröffentlicht: 22. August 2023
Gesehen am 25.10.2023
Physical Description:Online Resource
ISSN:2077-0383
DOI:10.3390/jcm12175454

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