The winner takes it all: competition drives clonal selection in gliomagenesis
The exact mechanisms that govern clonal dynamics and selection during early tumorigenesis remain largely elusive. Ceresa et al. provide experimental and mathematical evidence that MYC-dependent competition between individual clones is one driving force of brain tumor evolution, adding a winner/loser...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 August 2023
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| In: |
Cancer cell
Year: 2023, Volume: 41, Issue: 8, Pages: 1394-1396 |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2023.07.003 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ccell.2023.07.003 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S153561082300243X 
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| Author Notes: | Frank Winkler |
| Summary: | The exact mechanisms that govern clonal dynamics and selection during early tumorigenesis remain largely elusive. Ceresa et al. provide experimental and mathematical evidence that MYC-dependent competition between individual clones is one driving force of brain tumor evolution, adding a winner/loser aspect to the picture that complements existing concepts. |
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| Item Description: | Gesehen am 25.10.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2023.07.003 |