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Downregulation of miR-326 and its host gene β-arrestin1 induces pro-survival activity of E2F1 and promotes medulloblastoma growth

Medulloblastoma (MB) is a malignant pediatric brain tumor, and we reveal a new regulatory molecular axis critical for MB progression. Low expression of miR-326 and its host gene β-arrestin1 (ARRB1) promotes tumor growth enhancing the E2F1 pro-survival function. High levels of EZH2 are responsible fo...

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Main Authors: Miele, Evelina (Author) , Po, Agnese (Author) , Mastronuzzi, Angela (Author) , Carai, Andrea (Author) , Besharat, Zein Mersini (Author) , Pediconi, Natalia (Author) , Abballe, Luana (Author) , Catanzaro, Giuseppina (Author) , Sabato, Claudia (Author) , De Smaele, Enrico (Author) , Canettieri, Gianluca (Author) , Di Marcotullio, Lucia (Author) , Vacca, Alessandra (Author) , Mai, Antonello (Author) , Levrero, Massimo (Author) , Pfister, Stefan (Author) , Kool, Marcel (Author) , Giangaspero, Felice (Author) , Locatelli, Franco (Author) , Ferretti, Elisabetta (Author)
Format: Article (Journal)
Language:English
Published: February 2021
In: Molecular oncology
Year: 2021, Volume: 15, Issue: 2, Pages: 523-542
ISSN:1878-0261
DOI:10.1002/1878-0261.12800
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/1878-0261.12800
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12800
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Author Notes:Evelina Miele, Agnese Po, Angela Mastronuzzi, Andrea Carai, Zein Mersini Besharat, Natalia Pediconi, Luana Abballe, Giuseppina Catanzaro, Claudia Sabato, Enrico De Smaele, Gianluca Canettieri, Lucia Di Marcotullio, Alessandra Vacca, Antonello Mai, Massimo Levrero, Stefan M. Pfister, Marcel Kool, Felice Giangaspero, Franco Locatelli and Elisabetta Ferretti
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Summary:Medulloblastoma (MB) is a malignant pediatric brain tumor, and we reveal a new regulatory molecular axis critical for MB progression. Low expression of miR-326 and its host gene β-arrestin1 (ARRB1) promotes tumor growth enhancing the E2F1 pro-survival function. High levels of EZH2 are responsible for the presence of H3K27me3 that controls miR-326 and ARRB1 through a bivalent domain. Restoration of miR-326 and re-expression of ARRB1 reverse E2F1 function into pro-apoptotic activity.
Item Description:Online veröffentlicht: 13. September 2020
Gesehen am 26.10.2023
Physical Description:Online Resource
ISSN:1878-0261
DOI:10.1002/1878-0261.12800

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