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Distribution and prognostic impact of coronary artery disease and nonischemic cardiomyopathies in patients with electrical storm

Background: he distribution and prognostic impact of coronary artery disease (CAD) in ES are still under debate. Methods: Consecutive ES patients with implantable cardioverter-defibrillator (ICD) were included retrospectively from 2002 to 2016. Three analyses were applied to characterize ES patients...

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Main Authors: Müller, Julian (Author) , Behnes, Michael (Author) , Ellguth, Dominik (Author) , Schupp, Tobias (Author) , Taton, Gabriel (Author) , Reiser, Linda (Author) , Engelke, Niko (Author) , Borggrefe, Martin (Author) , Reichelt, Thomas (Author) , Kern-Bollow, Armin (Author) , Kim, Seung‑Hyun (Author) , Barth, Christian (Author) , Weidner, Kathrin (Author) , El-Battrawy, Ibrahim (Author) , Ansari, Uzair (Author) , Akın, Muharrem (Author) , Große Meininghaus, Dirk (Author) , Mashayekhi, Kambis (Author) , Akın, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: August 2022
In: Coronary artery disease
Year: 2022, Volume: 33, Issue: 5, Pages: 403-412
ISSN:1473-5830
DOI:10.1097/MCA.0000000000001140
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/MCA.0000000000001140
Verlag, lizenzpflichtig, Volltext: http://journals.lww.com/coronary-artery/abstract/2022/08000/distribution_and_prognostic_impact_of_coronary.9.aspx
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Author Notes:Julian Müller, Michael Behnes, Dominik Ellguth, Tobias Schupp, Gabriel Taton, Linda Reiser, Niko Engelke, Martin Borggrefe, Thomas Reichelt, Armin Bollow, Seung-Hyun Kim, Christian Barth, Kathrin Weidner, Ibrahim-El- Battrawy, Uzair Ansari, Muharrem Akin, Dirk Große Meininghaus, Kambis Mashayekhi, Ibrahim Akin
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Summary:Background: he distribution and prognostic impact of coronary artery disease (CAD) in ES are still under debate. Methods: Consecutive ES patients with implantable cardioverter-defibrillator (ICD) were included retrospectively from 2002 to 2016. Three analyses were applied to characterize ES patients: (a) ES patients without CAD (non-CAD), (b) ES patients with CAD (CAD), and (c) diagnostic findings assessed by coronary angiography (CA) at the time of ES (immediate CA). CAD was compared with non-CAD ES patients, and progressive CAD was compared with stable CAD ES patients. The primary endpoint was all-cause mortality at 2.5 years. Secondary endpoints were the composite endpoint of first recurrent ventricular tachyarrhythmias and appropriate ICD therapies, and recurrence of ES (ES-R) at 2.5 years.Results: Within a total of 87 consecutive ES patients. CAD was present in more than two-thirds (67%). However, only 52% patients underwent immediate CA at the time of ES. Here, 84% had CAD, of which 39% revealed progressive CAD with the need of target vessel revascularization (TVR) or cardiac transplantation (n = 1). At long-term follow-up, neither the presence (or absence) of CAD (41% vs. 34%; log rank P = 0.708) nor of progressive CAD (33% vs. 26%; log rank P = 0.372) was associated with all-cause mortality at 2.5 years, and further secondary endpoints including the composite of recurrent ventricular tachyarrhythmias plus appropriate ICD therapies, or ES-R. Conclusion: In ES patients, CAD was more common than non-CAD-related cardiac diseases, accompanied by an underinvestigated rate of CA despite increasing rates of progressive CAD. CAD had no prognostic impact in ES.
Item Description:Gesehen am 30.10.2023
Physical Description:Online Resource
ISSN:1473-5830
DOI:10.1097/MCA.0000000000001140

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