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Independent effects of kidney function and cholesterol efflux on cardiovascular mortality

Background: Impaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (CKD). This has been attributed to abnormal HDL function in CK...

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Main Authors: Ritsch, Andreas (Author) , Hunjadi, Monika (Author) , Stojakovic, Tatjana (Author) , Scherberich, Jürgen E. (Author) , Silbernagel, Günther (Author) , Scharnagl, Hubert (Author) , Delgado Gonzales de Kleber, Graciela (Author) , Kleber, Marcus E. (Author) , März, Winfried (Author)
Format: Article (Journal)
Language:English
Published: 29 July 2022
In: Biomedicines
Year: 2022, Volume: 10, Issue: 8, Pages: 1-9
ISSN:2227-9059
DOI:10.3390/biomedicines10081832
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/biomedicines10081832
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2227-9059/10/8/1832
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Author Notes:Andreas Ritsch, Monika Hunjadi, Tatjana Stojakovic, Jürgen E. Scherberich, Günther Silbernagel, Hubert Scharnagl, Graciela E. Delgado, Marcus E. Kleber and Winfried März
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Summary:Background: Impaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (CKD). This has been attributed to abnormal HDL function in CKD. Methods: In this study, we analyzed the association of genetic markers for kidney function with cholesterol efflux capacity as one of the major HDL functions, as well as with cardiovascular mortality, in 2469 patients of the Ludwigshafen Risk and Cardiovascular Health Study who all underwent coronary angiography. Results: A genetic score of 53 SNPs associated with GRF and the uromodulin SNP rs12917707 were inversely correlated with cholesterol efflux capacity. This was in line with the observed association between cholesterol efflux capacity and kidney function in these patients. Adjustment for eGFR and uromodulin as markers of kidney function did not affect the relationship between cholesterol efflux and cardiovascular mortality. Conclusions: Our data propose the view that cholesterol efflux and kidney function are exerting their effects on cardiovascular mortality via different and independent pathways. Decreased cholesterol efflux may therefore not mediate the effects of impaired kidney function on cardiovascular mortality.
Item Description:Der Artikel gehört zum Special issue: 10th anniversary of biomedicines - genetics of cholesterol in cardiovascular disease
Gesehen am 31.10.2023
Physical Description:Online Resource
ISSN:2227-9059
DOI:10.3390/biomedicines10081832

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