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The 4q12 amplicon in malignant peripheral nerve sheath tumors: consequences on gene expression and implications for sunitinib treatment

Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive tumors which originate from Schwann cells and develop in about 10% of neurofibromatosis type 1 (NF1) patients. The five year survival rate is poor and more effective therapies are needed. Sunitinib is a drug targeting receptor ty...

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Bibliographic Details
Main Authors: Zietsch, Jan (Author) , Ziegenhagen, Nicolas (Author) , Heppner, Frank L. (Author) , Reuss, David (Author) , Deimling, Andreas von (Author) , Holtkamp, Nikola (Author)
Format: Article (Journal)
Language:English
Published: July 29, 2010
In: PLOS ONE
Year: 2010, Volume: 5, Issue: 7, Pages: 1-10
ISSN:1932-6203
DOI:10.1371/journal.pone.0011858
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1371/journal.pone.0011858
Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011858
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Author Notes:Jan Zietsch, Nicolas Ziegenhagen, Frank L. Heppner, David Reuss, Andreas von Deimling, Nikola Holtkamp
Description
Summary:Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive tumors which originate from Schwann cells and develop in about 10% of neurofibromatosis type 1 (NF1) patients. The five year survival rate is poor and more effective therapies are needed. Sunitinib is a drug targeting receptor tyrosine kinases (RTK) like PDGFRα, c-Kit and VEGFR-2. These genes are structurally related and cluster on chromosomal segment 4q12.
Item Description:Gesehen am 31.10.2023
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0011858

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