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Clusterin facilitates COMMD1 and I-κB degradation to enhance NF-κB activity in prostate cancer cells

Secretory clusterin (sCLU) is a stress-activated, cytoprotective chaperone that confers broad-spectrum cancer treatment resistance, and its targeted inhibitor (OGX-011) is currently in phase II trials for prostate, lung, and breast cancer. However, the molecular mechanisms by which sCLU inhibits tre...

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Main Authors: Zoubeidi, Amina (Author) , Ettinger, Susan (Author) , Beraldi, Eliana (Author) , Hadaschik, Boris (Author) , Zardan, Anousheh (Author) , Klomp, Leo W.J. (Author) , Nelson, Colleen C. (Author) , Rennie, Paul S. (Author) , Gleave, Martin E. (Author)
Format: Article (Journal)
Language:English
Published: 1/12/10
In: Molecular cancer research
Year: 2010, Volume: 8, Issue: 1, Pages: 119-130
ISSN:1557-3125
DOI:10.1158/1541-7786.MCR-09-0277
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1158/1541-7786.MCR-09-0277
Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/mcr/article/8/1/119/90529/Clusterin-Facilitates-COMMD1-and-I-B-Degradation
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Author Notes:Amina Zoubeidi, Susan Ettinger, Eliana Beraldi, Boris Hadaschik, Anousheh Zardan, Leo W.J. Klomp, Colleen C. Nelson, Paul S. Rennie, and Martin E. Gleave
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Summary:Secretory clusterin (sCLU) is a stress-activated, cytoprotective chaperone that confers broad-spectrum cancer treatment resistance, and its targeted inhibitor (OGX-011) is currently in phase II trials for prostate, lung, and breast cancer. However, the molecular mechanisms by which sCLU inhibits treatment-induced apoptosis in prostate cancer remain incompletely defined. We report that sCLU increases NF-κB nuclear translocation and transcriptional activity by serving as a ubiquitin-binding protein that enhances COMMD1 and I-κB proteasomal degradation by interacting with members of the SCF-βTrCP E3 ligase family. ...
Item Description:Im Titel wird bei den Begriffen I-κB und NF-κB das verkleinert erscheinende "K" durch den griechischen Buchstaben Kappa dargestellt
Online veröffentlicht am 12. Januar 2010
Gesehen am 31.10.2023
Physical Description:Online Resource
ISSN:1557-3125
DOI:10.1158/1541-7786.MCR-09-0277

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