Clusterin facilitates COMMD1 and I-κB degradation to enhance NF-κB activity in prostate cancer cells
Secretory clusterin (sCLU) is a stress-activated, cytoprotective chaperone that confers broad-spectrum cancer treatment resistance, and its targeted inhibitor (OGX-011) is currently in phase II trials for prostate, lung, and breast cancer. However, the molecular mechanisms by which sCLU inhibits tre...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1/12/10
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| In: |
Molecular cancer research
Year: 2010, Volume: 8, Issue: 1, Pages: 119-130 |
| ISSN: | 1557-3125 |
| DOI: | 10.1158/1541-7786.MCR-09-0277 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1158/1541-7786.MCR-09-0277 Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/mcr/article/8/1/119/90529/Clusterin-Facilitates-COMMD1-and-I-B-Degradation 
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| Author Notes: | Amina Zoubeidi, Susan Ettinger, Eliana Beraldi, Boris Hadaschik, Anousheh Zardan, Leo W.J. Klomp, Colleen C. Nelson, Paul S. Rennie, and Martin E. Gleave |
MARC
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| 520 | |a Secretory clusterin (sCLU) is a stress-activated, cytoprotective chaperone that confers broad-spectrum cancer treatment resistance, and its targeted inhibitor (OGX-011) is currently in phase II trials for prostate, lung, and breast cancer. However, the molecular mechanisms by which sCLU inhibits treatment-induced apoptosis in prostate cancer remain incompletely defined. We report that sCLU increases NF-κB nuclear translocation and transcriptional activity by serving as a ubiquitin-binding protein that enhances COMMD1 and I-κB proteasomal degradation by interacting with members of the SCF-βTrCP E3 ligase family. ... | ||
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