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Global genome analysis of the shikimic acid pathway reveals greater gene loss in host-associated than in free-living bacteria

A central tenet in biochemistry for over 50 years has held that microorganisms, plants and, more recently, certain apicomplexan parasites synthesize essential aromatic compounds via elaboration of a complete shikimic acid pathway, whereas metazoans lacking this pathway require a dietary source of th...

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Main Authors: Žučko, Jurica (Author) , Dunlap, Walter C. (Author) , Shick, J. Malcolm (Author) , Cullum, John (Author) , Cercelet, François (Author) , Amin, Bijal (Author) , Hammen, Lena (Author) , Lau, Timothy (Author) , Williams, Jamal (Author) , Hranueli, Daslav (Author) , Long, Paul F. (Author)
Format: Article (Journal)
Language:English
Published: 11 November 2010
In: BMC genomics
Year: 2010, Volume: 11, Pages: 1-10
ISSN:1471-2164
DOI:10.1186/1471-2164-11-628
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2164-11-628
Verlag, lizenzpflichtig, Volltext: https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-11-628
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Author Notes:Jurica Zucko, Walter C. Dunlap, J. Malcolm Shick, John Cullum, François Cercelet, Bijal Amin, Lena Hammen, Timothy Lau, Jamal Williams, Daslav Hranueli, Paul F. Long
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Summary:A central tenet in biochemistry for over 50 years has held that microorganisms, plants and, more recently, certain apicomplexan parasites synthesize essential aromatic compounds via elaboration of a complete shikimic acid pathway, whereas metazoans lacking this pathway require a dietary source of these compounds. The large number of sequenced bacterial and archaean genomes now available for comparative genomic analyses allows the fundamentals of this contention to be tested in prokaryotes. Using Hidden Markov Model profiles (HMM profiles) to identify all known enzymes of the pathway, we report the presence of genes encoding shikimate pathway enzymes in the hypothetical proteomes constructed from the genomes of 488 sequenced prokaryotes.
Item Description:Gesehen am 31.10.2023
Physical Description:Online Resource
ISSN:1471-2164
DOI:10.1186/1471-2164-11-628

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