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Cell-cell interactions drive metastasis of circulating tumor microemboli

Circulating tumor cells are the cellular mediators of distant metastasis in solid malignancies. Their metastatic potential can be augmented by clustering with other tumor cells or nonmalignant cells, forming circulating tumor microemboli (CTM). Cell-cell interactions are key regulators within CTM th...

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Bibliographic Details
Main Authors: Tao, Jianxin (Author) , Zhu, Lei (Author) , Yakoub, Mina (Author) , Reißfelder, Christoph (Author) , Loges, Sonja (Author) , Schölch, Sebastian (Author)
Format: Article (Journal)
Language:English
Published: August 03 2022
In: Cancer research
Year: 2022, Volume: 82, Issue: 15, Pages: 2661-2671
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-22-0906
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/0008-5472.CAN-22-0906
Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/cancerres/article/82/15/2661/707329/Cell-Cell-Interactions-Drive-Metastasis-of
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Author Notes:Jianxin Tao, Lei Zhu, Mina Yakoub, Christoph Reißfelder, Sonja Loges, and Sebastian Schölch
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Summary:Circulating tumor cells are the cellular mediators of distant metastasis in solid malignancies. Their metastatic potential can be augmented by clustering with other tumor cells or nonmalignant cells, forming circulating tumor microemboli (CTM). Cell-cell interactions are key regulators within CTM that convey enhanced metastatic properties, including improved cell survival, immune evasion, and effective extravasation into distant organs. However, the cellular and molecular mechanism of CTM formation, as well as the biology of interactions between tumor cells and immune cells, platelets, and stromal cells in the circulation, remains to be determined. Here, we review the current literature on cell-cell interactions in homotypic and heterotypic CTM and provide perspectives on therapeutic strategies to attenuate CTM-mediated metastasis by targeting cell-cell interactions.
Item Description:Gesehen am 06.11.2023
Physical Description:Online Resource
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-22-0906

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