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DELMEP: a deep learning algorithm for automated annotation of motor evoked potential latencies

The analysis of motor evoked potentials (MEPs) generated by transcranial magnetic stimulation (TMS) is crucial in research and clinical medical practice. MEPs are characterized by their latency and the treatment of a single patient may require the characterization of thousands of MEPs. Given the dif...

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Main Authors: Milardovich, Diego (Author) , Souza, Victor H. (Author) , Zubarev, Ivan (Author) , Tugin, Sergei (Author) , Nieminen, Jaakko O. (Author) , Bigoni, Claudia (Author) , Hummel, Friedhelm C. (Author) , Korhonen, Juuso T. (Author) , Aydogan, Dogu B. (Author) , Lioumis, Pantelis (Author) , Taherinejad, Nima (Author) , Grasser, Tibor (Author) , Ilmoniemi, Risto J. (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Scientific reports
Year: 2023, Volume: 13, Pages: 1-11
ISSN:2045-2322
DOI:10.1038/s41598-023-34801-9
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-023-34801-9
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-023-34801-9
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Author Notes:Diego Milardovich, Victor H. Souza, Ivan Zubarev, Sergei Tugin, Jaakko O. Nieminen, Claudia Bigoni, Friedhelm C. Hummel, Juuso T. Korhonen, Dogu B. Aydogan, Pantelis Lioumis, Nima Taherinejad, Tibor Grasser & Risto J. Ilmoniemi
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Summary:The analysis of motor evoked potentials (MEPs) generated by transcranial magnetic stimulation (TMS) is crucial in research and clinical medical practice. MEPs are characterized by their latency and the treatment of a single patient may require the characterization of thousands of MEPs. Given the difficulty of developing reliable and accurate algorithms, currently the assessment of MEPs is performed with visual inspection and manual annotation by a medical expert; making it a time-consuming, inaccurate, and error-prone process. In this study, we developed DELMEP, a deep learning-based algorithm to automate the estimation of MEP latency. Our algorithm resulted in a mean absolute error of about 0.5 ms and an accuracy that was practically independent of the MEP amplitude. The low computational cost of the DELMEP algorithm allows employing it in on-the-fly characterization of MEPs for brain-state-dependent and closed-loop brain stimulation protocols. Moreover, its learning ability makes it a particularly promising option for artificial-intelligence-based personalized clinical applications.
Item Description:Veröffentlicht: 22. Mai 2023
Gesehen am 14.11.2023
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-023-34801-9

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