Superhydrophobic-superhydrophilic micropatterning: towards genome-on-a-chip cell microarrays

High-density cell microarrays based on superhydrophilic microspots separated by superhydrophobic barriers have been realized. The microspots absorb water solutions, while the barriers prevent cross-contamination, thus allowing the spots to be used as reservoirs for transfection mixtures and preventi...

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Bibliographic Details
Main Authors: Geyer, Florian Ludwig (Author) , Ueda, Erica (Author) , Liebel, Urban (Author) , Grau, Nicole (Author) , Levkin, Pavel (Author)
Format: Article (Journal)
Language:English
Published: July 12, 2011
In: Angewandte Chemie. International edition
Year: 2011, Volume: 50, Issue: 36, Pages: 8424-8427
ISSN:1521-3773
DOI:10.1002/anie.201102545
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/anie.201102545
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201102545
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Author Notes:Florian L. Geyer, Erica Ueda, Urban Liebel, Nicole Grau, and Pavel A. Levkin
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Summary:High-density cell microarrays based on superhydrophilic microspots separated by superhydrophobic barriers have been realized. The microspots absorb water solutions, while the barriers prevent cross-contamination, thus allowing the spots to be used as reservoirs for transfection mixtures and preventing cell proliferation and cell migration between the microspots. The picture shows four cell types after two days of culturing on the microarray.
Item Description:Gesehen am 14.11.2023
Physical Description:Online Resource
ISSN:1521-3773
DOI:10.1002/anie.201102545