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APP family member dimeric complexes are formed predominantly in synaptic compartments

The amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and APLP2. They share similar structures, form homo- and heterotypic dimers and exhibit overlapping functions.

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Bibliographic Details
Main Authors: Schilling, Sandra (Author) , August, Alexander (Author) , Meleux, Mathieu (Author) , Conradt, Carolin (Author) , Tremmel, Luisa M. (Author) , Teigler, Sandra (Author) , Adam, Virginie (Author) , Müller, Ulrike C. (Author) , Koo, Edward H. (Author) , Kins, Stefan (Author) , Eggert, Simone (Author)
Format: Article (Journal)
Language:English
Published: 02 August 2023
In: Cell & bioscience
Year: 2023, Volume: 13, Pages: 1-24
ISSN:2045-3701
DOI:10.1186/s13578-023-01092-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13578-023-01092-6
Verlag, kostenfrei, Volltext: https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-023-01092-6
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Author Notes:Sandra Schilling, Alexander August, Mathieu Meleux, Carolin Conradt, Luisa M. Tremmel, Sandra Teigler, Virginie Adam, Ulrike C. Müller, Edward H. Koo, Stefan Kins and Simone Eggert
Description
Summary:The amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and APLP2. They share similar structures, form homo- and heterotypic dimers and exhibit overlapping functions.
Item Description:Gesehen am 14.11.2023
Physical Description:Online Resource
ISSN:2045-3701
DOI:10.1186/s13578-023-01092-6

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