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P50 gating deficit in Alzheimer dementia correlates to frontal neuropsychological function

Background - Cognitive inhibition processes were found to be deficient early in the clinical course of Alzheimer's disease (AD). The inhibition of redundant information is a precondition for efficient cognitive processing and presumably modulated by prefrontal attentional networks. Deficits in...

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Main Authors: Thomas, Christine (Author) , Berg, Ingo vom (Author) , Rupp, André (Author) , Seidl, Ulrich (Author) , Schröder, Johannes (Author) , Roesch-Ely, Daniela (Author) , Kreisel, Stefan H. (Author) , Mundt, Christoph (Author) , Weisbrod, Matthias (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Neurobiology of aging
Year: 2010, Volume: 31, Issue: 3, Pages: 416-424
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2008.05.002
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neurobiolaging.2008.05.002
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0197458008001474
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Author Notes:Christine Thomas, Ingo vom Berg, Andre Rupp, Ulrich Seidl, Johannes Schröder, Daniela Roesch-Ely, Stefan H. Kreisel, Christoph Mundt, Matthias Weisbrod
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Summary:Background - Cognitive inhibition processes were found to be deficient early in the clinical course of Alzheimer's disease (AD). The inhibition of redundant information is a precondition for efficient cognitive processing and presumably modulated by prefrontal attentional networks. Deficits in the suppression of the evoked potential P50 response to paired clicks are well known in schizophrenic patients and undergo cholinergic modulation. In this study, we aimed to investigate inhibitory gating deficits of P50 in AD and their relation to neuropsychological measures. - Method - P50 suppression was assessed in 19 AD-patients in comparison to a young and elderly control group (n=17 each) and related to MMSE and specific neuropsychological assessments. - Results - Patients showed reduced sensory gating compared to healthy elderly (p<0.021) and exhibited significantly higher N40-P50-amplitudes. There were no age or gender effects in controls. Frontal neuropsychological tests (TMT-B, verbal fluency) and working memory requiring inhibition, but not declarative memory functions, were significantly correlated with inhibitory gating and test amplitude in both, AD-patients and controls. - Conclusions - The results support an early inhibitory deficit interfering with executive functions and working memory in AD independent from physiological aging. P50 gating might be applicable as a marker for inhibition deficits and thereby be important for prognosis estimation.
Item Description:Erstmals am 17 June 2008 online veröffentlicht
Gesehen am 15.11.2023
Physical Description:Online Resource
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2008.05.002

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