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Cost-effectiveness of low-complexity screening tests in community-based case-finding for tuberculosis

In high-burden settings, low-complexity screening tests for tuberculosis (TB) could expand the reach of community-based case-finding efforts. The potential costs and cost-effectiveness of approaches incorporating these tests are poorly understood.We developed a microsimulation model assessing 3 appr...

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Hauptverfasser: Brümmer, Lukas E. (VerfasserIn) , Thompson, Ryan R. (VerfasserIn) , Malhotra, Akash (VerfasserIn) , Shrestha, Sourya (VerfasserIn) , Kendall, Emily A. (VerfasserIn) , Andrews, Jason R. (VerfasserIn) , Phillips, Patrick (VerfasserIn) , Nahid, Payam (VerfasserIn) , Cattamanchi, Adithya (VerfasserIn) , Marx, Florian (VerfasserIn) , Denkinger, Claudia M. (VerfasserIn) , Dowdy, David W. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2024
In: Clinical infectious diseases
Year: 2024, Jahrgang: 78, Heft: 1, Pages: 154-163
ISSN:1537-6591
DOI:10.1093/cid/ciad501
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/cid/ciad501
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Verfasserangaben:Lukas E. Brümmer, Ryan R. Thompson, Akash Malhotra, Sourya Shrestha, Emily A. Kendall, Jason R. Andrews, Patrick Phillips, Payam Nahid, Adithya Cattamanchi, Florian M. Marx, Claudia M. Denkinger, and David W. Dowdy
Beschreibung
Zusammenfassung:In high-burden settings, low-complexity screening tests for tuberculosis (TB) could expand the reach of community-based case-finding efforts. The potential costs and cost-effectiveness of approaches incorporating these tests are poorly understood.We developed a microsimulation model assessing 3 approaches to community-based case-finding in hypothetical populations (India-, South Africa-, The Philippines-, Uganda-, and Vietnam-like settings) with TB prevalence 4 times that of national estimates: (1) screening with a point-of-care C-reactive protein (CRP) test, (2) screening with a more sensitive “Hypothetical Screening test” (95% sensitive for Xpert Ultra-positive TB, 70% specificity; equipment/labor costs similar to Xpert Ultra, but using a
Beschreibung:Online veröffentlicht 25.August 2023
Gesehen am 14.10.2025
Beschreibung:Online Resource
ISSN:1537-6591
DOI:10.1093/cid/ciad501

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