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Comprehensive genomic profiling of carcinoma of unknown primary origin: retrospective molecular classification considering the CUPISCO study design

Background. Carcinoma of unknown primary origin (CUP) accounts for 2%-5% of newly diagnosed advanced malignancies, with chemotherapy as the standard of care. CUPISCO (NCT03498521) is an ongoing randomized trial using comprehensive genomic profiling (CGP) to assign patients with CUP to targeted or imm...

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Main Authors: Ross, Jeffrey S. (Author) , Sokol, Ethan S. (Author) , Moch, Holger (Author) , Mileshkin, Linda (Author) , Baciarello, Giulia (Author) , Losa, Ferran (Author) , Beringer, Andreas (Author) , Thomas, Marlene (Author) , Elvin, Julia A. (Author) , Ngo, Nhu (Author) , Jin, Dexter X. (Author) , Krämer, Alwin (Author)
Format: Article (Journal)
Language:English
Published: March 2021
In: The oncologist
Year: 2021, Volume: 26, Issue: 3, Pages: e394-e402
ISSN:1549-490X
DOI:10.1002/onco.13597
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/onco.13597
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/oncolo/article/26/3/e394/6445517
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Author Notes:Jeffrey S. Ross, Ethan S. Sokol, Holger Moch, Linda Mileshkin, Giulia Baciarello, Ferran Losa, Andreas Beringer, Marlene Thomas, Julia A. Elvin, Nhu Ngo, Dexter X. Jin, Alwin Krämer
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Summary:Background. Carcinoma of unknown primary origin (CUP) accounts for 2%-5% of newly diagnosed advanced malignancies, with chemotherapy as the standard of care. CUPISCO (NCT03498521) is an ongoing randomized trial using comprehensive genomic profiling (CGP) to assign patients with CUP to targeted or immunotherapy treatment arms based on genomic profiling. We performed a retrospective analysis of CUP cases referred for CGP to determine how many were potentially eligible for enrollment into an experimental CUPISCO arm.
Item Description:Online veröffentlicht: 14. Dezember 2020
Gesehen am 15.11.2023
Physical Description:Online Resource
ISSN:1549-490X
DOI:10.1002/onco.13597

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