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Spectral imaging enables contrast agent-free real-time ischemia in laparoscopic

Laparoscopic surgery has evolved as a key technique for cancer diagnosis and therapy. While characterization of the tissue perfusion is crucial in various procedures, such as partial nephrectomy, doing so by means of visual inspection remains highly challenging. We developed a laparoscopic real-time...

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Main Authors: Ayala, Leonardo (Author) , Adler, Tim (Author) , Seidlitz, Silvia (Author) , Wirkert, Sebastian (Author) , Engels, Christina (Author) , Seitel, Alexander (Author) , Sellner, Jan (Author) , Aksenov, Alexey (Author) , Bodenbach, Matthias (Author) , Bader, Pia (Author) , Baron, Sebastian (Author) , Vemuri, Anant (Author) , Wiesenfarth, Manuel (Author) , Schreck, Nicholas (Author) , Mindroc, Diana (Author) , Tizabi, Minu (Author) , Pirmann, Sebastian (Author) , Everitt, Brittaney (Author) , Kopp-Schneider, Annette (Author) , Teber, Dogu (Author) , Maier-Hein, Lena (Author)
Format: Article (Journal)
Language:English
Published: 10 March 2023
In: Science advances
Year: 2023, Volume: 9, Issue: 10, Pages: 1-17
ISSN:2375-2548
DOI:10.1126/sciadv.add6778
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciadv.add6778
Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/pdf/10.1126/sciadv.add6778?download=true
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Author Notes:Leonardo Ayala, Tim J. Adler, Silvia Seidlitz, Sebastian Wirkert, Christina Engels, Alexander Seitel, Jan Sellner, Alexey Aksenov, Matthias Bodenbach, Pia Bader, Sebastian Baron, Anant Vemuri, Manuel Wiesenfarth, Nicholas Schreck, Diana Mindroc, Minu Tizabi, Sebastian Pirmann, Brittaney Everitt, Annette Kopp-Schneider, Dogu Teber, Lena Maier-Hein
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Summary:Laparoscopic surgery has evolved as a key technique for cancer diagnosis and therapy. While characterization of the tissue perfusion is crucial in various procedures, such as partial nephrectomy, doing so by means of visual inspection remains highly challenging. We developed a laparoscopic real-time multispectral imaging system featuring a compact and lightweight multispectral camera and the possibility to complement the conventional surgical view of the patient with functional information at a video rate of 25 Hz. To enable contrast agent-free ischemia monitoring during laparoscopic partial nephrectomy, we phrase the problem of ischemia detection as an out-of-distribution detection problem that does not rely on data from any other patient and uses an ensem-ble of invertible neural networks at its core. An in-human trial demonstrates the feasibility of our approach and highlights the potential of spectral imaging combined with advanced deep learning-based analysis tools for fast, efficient, reliable, and safe functional laparoscopic imaging.
Item Description:Gesehen am 20.11.2023
Physical Description:Online Resource
ISSN:2375-2548
DOI:10.1126/sciadv.add6778

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