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Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Background - Antihypertensive and tissue-protective properties of vitamin D metabolites are increasingly attributed to the inhibition of renin synthesis by 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney. - Method - We aimed to document a potential association between 25-hydroxyvitamin D [25(OH)D...

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Main Authors: Tomaschitz, Andreas (Author) , Pilz, Stefan (Author) , Ritz, Eberhard (Author) , Grammer, Tanja B. (Author) , Drechsler, Christiane (Author) , Boehm, Bernhard O. (Author) , März, Winfried (Author)
Format: Article (Journal)
Language:English
Published: 1 June 2010
In: Clinica chimica acta
Year: 2010, Volume: 411, Issue: 17/18, Pages: 1354-1360
ISSN:1873-3492
DOI:10.1016/j.cca.2010.05.037
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cca.2010.05.037
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0009898110003700
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Author Notes:Andreas Tomaschitz, Stefan Pilz, Eberhard Ritz, Tanja Grammer, Christiane Drechsler, Bernhard O. Boehm, Winfried März
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Summary:Background - Antihypertensive and tissue-protective properties of vitamin D metabolites are increasingly attributed to the inhibition of renin synthesis by 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney. - Method - We aimed to document a potential association between 25-hydroxyvitamin D [25(OH)D], 1,25(OH)2D and the circulating renin-angiotensin system (RAS) in a large cohort of patients referred (n=3316) to coronary angiography. - Results - Of the 3316 subjects, 3296 (median age: 63.5 (56.3-70.6)years; 30.2% women) had a baseline measurement of 25(OH)D [median: 15.6(10.1-23.0)µg/L)], 1,25(OH)2D [median: 33.2(25.2-42.9)pg/mL], plasma renin concentration [PRC; median: 11.4(6.0-24.6)pg/mL] and angiotensin 2 [median: 20.0(12.0-35.0)ng/L]. Multivariate adjusted ANCOVA showed a steady increase of PRC values across declining deciles of 25(OH)D and 1,25(OH)2D values (P=0.013 and P=0.045), respectively. Additionally, mean angiotensin 2 values increased significantly across decreasing 25(OH)D and 1,25(OH)2D values (P=0.020 and P=0.024, respectively). In contrast, multivariate adjusted ANCOVA revealed no significant associations between aldosterone, aldosterone-to-renin ratio and 25(OH)D/1,25(OH)2D values. In multivariate stepwise regression analyses both, 25(OH)D and 1,25(OH)2D emerged as independent predictors of plasma renin and angiotensin 2 concentrations. - Conclusions - Our data showed for the first time in humans that both, lower 25(OH)D and 1,25(OH)2D values are independently related to an upregulated circulating RAS.
Item Description:Gesehen am 28.11.2023
Physical Description:Online Resource
ISSN:1873-3492
DOI:10.1016/j.cca.2010.05.037

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