Sex-biased gene expression across mammalian organ development and evolution
Sexually dimorphic traits are common among mammals and are specified during development through the deployment of sex-specific genetic programs. Because little is known about these programs, we investigated them using a resource of gene expression profiles in males and females throughout the develop...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 Nov 2023
|
| In: |
Science
Year: 2023, Jahrgang: 382, Pages: 1-13 |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.adf1046 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.adf1046 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/science.adf1046 
|
| Verfasserangaben: | Leticia Rodríguez-Montes, Svetlana Ovchinnikova, Xuefei Yuan, Tania Studer, Ioannis Sarropoulos, Simon Anders, Henrik Kaessmann, Margarida Cardoso-Moreira |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1871454441 | ||
| 003 | DE-627 | ||
| 005 | 20240307040054.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231128s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1126/science.adf1046 |2 doi | |
| 035 | |a (DE-627)1871454441 | ||
| 035 | |a (DE-599)KXP1871454441 | ||
| 035 | |a (OCoLC)1425209078 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Rodríguez Montes, Leticia |e VerfasserIn |0 (DE-588)1311445773 |0 (DE-627)1871455553 |4 aut | |
| 245 | 1 | 0 | |a Sex-biased gene expression across mammalian organ development and evolution |c Leticia Rodríguez-Montes, Svetlana Ovchinnikova, Xuefei Yuan, Tania Studer, Ioannis Sarropoulos, Simon Anders, Henrik Kaessmann, Margarida Cardoso-Moreira |
| 264 | 1 | |c 3 Nov 2023 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.11.2023 | ||
| 520 | |a Sexually dimorphic traits are common among mammals and are specified during development through the deployment of sex-specific genetic programs. Because little is known about these programs, we investigated them using a resource of gene expression profiles in males and females throughout the development of five organs in five mammals (human, mouse, rat, rabbit, and opossum) and a bird (chicken). We found that sex-biased gene expression varied considerably across organs and species and was often cell-type specific. Sex differences increased abruptly around sexual maturity instead of increasing gradually during organ development. Finally, sex-biased gene expression evolved rapidly at the gene level, with differences between organs in the evolutionary mechanisms used, but more slowly at the cellular level, with the same cell types being sexually dimorphic across species. | ||
| 700 | 1 | |a Ovchinnikova, Svetlana |d 1990- |e VerfasserIn |0 (DE-588)1195738366 |0 (DE-627)1677805978 |4 aut | |
| 700 | 1 | |a Yuan, Xuefei |e VerfasserIn |0 (DE-588)1262524431 |0 (DE-627)1810226686 |4 aut | |
| 700 | 1 | |a Studer, Tania |e VerfasserIn |0 (DE-588)1163125121 |0 (DE-627)1027349285 |0 (DE-576)507801350 |4 aut | |
| 700 | 1 | |a Sarropoulos, Ioannis |d 1992- |e VerfasserIn |0 (DE-588)1205172912 |0 (DE-627)1690640693 |4 aut | |
| 700 | 1 | |a Anders, Simon |e VerfasserIn |0 (DE-588)1184492964 |0 (DE-627)1663597936 |4 aut | |
| 700 | 1 | |a Kaessmann, Henrik |d 1971- |e VerfasserIn |0 (DE-588)123405874 |0 (DE-627)706287592 |0 (DE-576)184072301 |4 aut | |
| 700 | 1 | |a Cardoso-Moreira, Margarida |e VerfasserIn |0 (DE-588)1172449465 |0 (DE-627)1041212127 |0 (DE-576)514629045 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Science |d Washington, DC : American Association for the Advancement of Science, 1880 |g 382(2023), Artikel-ID 6670, Seite 1-13 |h Online-Ressource |w (DE-627)341342882 |w (DE-600)2066996-3 |w (DE-576)099426773 |x 1095-9203 |7 nnas |a Sex-biased gene expression across mammalian organ development and evolution |
| 773 | 1 | 8 | |g volume:382 |g year:2023 |g elocationid:6670 |g pages:1-13 |g extent:13 |a Sex-biased gene expression across mammalian organ development and evolution |
| 856 | 4 | 0 | |u https://doi.org/10.1126/science.adf1046 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.science.org/doi/10.1126/science.adf1046 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231128 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1172449465 |a Cardoso-Moreira, Margarida |m 1172449465:Cardoso-Moreira, Margarida |p 8 |y j | ||
| 998 | |g 123405874 |a Kaessmann, Henrik |m 123405874:Kaessmann, Henrik |d 700000 |d 706000 |e 700000PK123405874 |e 706000PK123405874 |k 0/700000/ |k 1/700000/706000/ |p 7 | ||
| 998 | |g 1184492964 |a Anders, Simon |m 1184492964:Anders, Simon |d 700000 |d 716000 |e 700000PA1184492964 |e 716000PA1184492964 |k 0/700000/ |k 1/700000/716000/ |p 6 | ||
| 998 | |g 1205172912 |a Sarropoulos, Ioannis |m 1205172912:Sarropoulos, Ioannis |d 700000 |d 706000 |e 700000PS1205172912 |e 706000PS1205172912 |k 0/700000/ |k 1/700000/706000/ |p 5 | ||
| 998 | |g 1163125121 |a Studer, Tania |m 1163125121:Studer, Tania |p 4 | ||
| 998 | |g 1262524431 |a Yuan, Xuefei |m 1262524431:Yuan, Xuefei |d 700000 |d 706000 |e 700000PY1262524431 |e 706000PY1262524431 |k 0/700000/ |k 1/700000/706000/ |p 3 | ||
| 998 | |g 1195738366 |a Ovchinnikova, Svetlana |m 1195738366:Ovchinnikova, Svetlana |d 700000 |d 716000 |e 700000PO1195738366 |e 716000PO1195738366 |k 0/700000/ |k 1/700000/716000/ |p 2 | ||
| 998 | |g 1311445773 |a Rodríguez Montes, Leticia |m 1311445773:Rodríguez Montes, Leticia |d 700000 |d 706000 |e 700000PR1311445773 |e 706000PR1311445773 |k 0/700000/ |k 1/700000/706000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1871454441 |e 4419748842 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"3 Nov 2023"}],"language":["eng"],"relHost":[{"part":{"text":"382(2023), Artikel-ID 6670, Seite 1-13","extent":"13","volume":"382","pages":"1-13","year":"2023"},"type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"Science / Magazine"},{"title":"Science classic"},{"title":"Science classic archiv 1880 - 1996"},{"title":"Science magazine"}],"title":[{"title_sort":"Science","title":"Science"}],"recId":"341342882","id":{"issn":["1095-9203"],"zdb":["2066996-3"],"eki":["341342882"]},"name":{"displayForm":["AAAS"]},"pubHistory":["1.1880 - 3.1882; 1.1883 - 23.1894; N.S. 1.1895 -"],"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 14.07.2023"],"language":["eng"],"disp":"Sex-biased gene expression across mammalian organ development and evolutionScience","corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"American Association for the Advancement of Science"}],"origin":[{"dateIssuedKey":"1880","publisherPlace":"Washington, DC","dateIssuedDisp":"1880-","publisher":"American Association for the Advancement of Science"}]}],"physDesc":[{"extent":"13 S."}],"note":["Gesehen am 28.11.2023"],"name":{"displayForm":["Leticia Rodríguez-Montes, Svetlana Ovchinnikova, Xuefei Yuan, Tania Studer, Ioannis Sarropoulos, Simon Anders, Henrik Kaessmann, Margarida Cardoso-Moreira"]},"id":{"eki":["1871454441"],"doi":["10.1126/science.adf1046"]},"recId":"1871454441","title":[{"title_sort":"Sex-biased gene expression across mammalian organ development and evolution","title":"Sex-biased gene expression across mammalian organ development and evolution"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"role":"aut","roleDisplay":"VerfasserIn","given":"Leticia","display":"Rodríguez Montes, Leticia","family":"Rodríguez Montes"},{"given":"Svetlana","roleDisplay":"VerfasserIn","display":"Ovchinnikova, Svetlana","family":"Ovchinnikova","role":"aut"},{"family":"Yuan","given":"Xuefei","roleDisplay":"VerfasserIn","display":"Yuan, Xuefei","role":"aut"},{"role":"aut","family":"Studer","roleDisplay":"VerfasserIn","given":"Tania","display":"Studer, Tania"},{"role":"aut","family":"Sarropoulos","roleDisplay":"VerfasserIn","display":"Sarropoulos, Ioannis","given":"Ioannis"},{"family":"Anders","given":"Simon","roleDisplay":"VerfasserIn","display":"Anders, Simon","role":"aut"},{"family":"Kaessmann","display":"Kaessmann, Henrik","roleDisplay":"VerfasserIn","given":"Henrik","role":"aut"},{"given":"Margarida","roleDisplay":"VerfasserIn","display":"Cardoso-Moreira, Margarida","family":"Cardoso-Moreira","role":"aut"}]} | ||
| SRT | |a RODRIGUEZMSEXBIASEDG3202 | ||