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Fast kilovoltage/megavoltage (kVMV) breathhold cone-beam CT for image-guided radiotherapy of lung cancer

Long image acquisition times of 60-120 s for cone-beam CT (CBCT) limit the number of patients with lung cancer who can undergo volume image guidance under breathhold. We developed a low-dose dual-energy kilovoltage-megavoltage-cone-beam CT (kVMV-CBCT) based on a clinical treatment unit reducing imag...

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Main Authors: Wertz, Hansjörg (Author) , Stsepankou, Dzmitry (Author) , Blessing, Manuel (Author) , Rossi, Michael (Author) , Knox, Chris (Author) , Brown, Kevin (Author) , Gros, Uwe (Author) , Boda-Heggemann, Judit (Author) , Walter, Cornelia (Author) , Hesser, Jürgen (Author) , Lohr, Frank (Author) , Wenz, Frederik (Author)
Format: Article (Journal)
Language:English
Published: 8 July 2010
In: Physics in medicine and biology
Year: 2010, Volume: 55, Issue: 15, Pages: 4203-4217
ISSN:1361-6560
DOI:10.1088/0031-9155/55/15/001
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1088/0031-9155/55/15/001
Verlag, lizenzpflichtig, Volltext: https://dx.doi.org/10.1088/0031-9155/55/15/001
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Author Notes:Hansjoerg Wertz, Dzmitry Stsepankou, Manuel Blessing, Michael Rossi, Chris Knox, Kevin Brown, Uwe Gros, Judit Boda-Heggemann, Cornelia Walter, Juergen Hesser, Frank Lohr and Frederik Wenz
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Summary:Long image acquisition times of 60-120 s for cone-beam CT (CBCT) limit the number of patients with lung cancer who can undergo volume image guidance under breathhold. We developed a low-dose dual-energy kilovoltage-megavoltage-cone-beam CT (kVMV-CBCT) based on a clinical treatment unit reducing imaging time to ⩽15 s. Simultaneous kVMV-imaging was achieved by dedicated synchronization hardware controlling the output of the linear accelerator (linac) based on detector panel readout signals, preventing imaging artifacts from interference of the linac's MV-irradiation and panel readouts. Optimization was performed to minimize the imaging dose. Single MV-projections, reconstructed MV-CBCT images and images of simultaneous 90° kV- and 90° MV-CBCT (180° kVMV-CBCT) were acquired with different parameters. Image quality and imaging dose were evaluated and compared to kV-imaging. Hardware-based kVMV synchronization resulted in artifact-free projections. A combined 180° kVMV-CBCT scan with a total MV-dose of 5 monitor units was acquired in 15 s and with sufficient image quality. The resolution was 5-6 line pairs cm−1 (Catphan phantom). The combined kVMV-scan dose was equivalent to a kV-radiation scan dose of ∼33 mGy. kVMV-CBCT based on a standard linac is promising and can provide ultra-fast online volume image guidance with low imaging dose and sufficient image quality for fast and accurate patient positioning for patients with lung cancer under breathhold.
Item Description:Gesehen am 29.11.2023
Physical Description:Online Resource
ISSN:1361-6560
DOI:10.1088/0031-9155/55/15/001

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