Classification of visual field abnormalities in highly myopic eyes without pathologic change
Purpose - To develop a classification system of visual field (VF) abnormalities in highly myopic eyes with and without glaucoma. - Design - Secondary analysis of VF data from a longitudinal cohort study. - Participants - One thousand eight hundred ninety-three VF tests from 1302 eyes (825 individual...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 2022
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| In: |
Ophthalmology
Year: 2022, Volume: 129, Issue: 7, Pages: 803-812 |
| ISSN: | 1549-4713 |
| DOI: | 10.1016/j.ophtha.2022.03.001 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ophtha.2022.03.001 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0161642022001932 
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| Author Notes: | Fengbin Lin, Shida Chen, Yunhe Song, Fei Li, Wei Wang, Zhenni Zhao, Xinbo Gao, Peiyuan Wang, Ling Jin, Yuhong Liu, Meiling Chen, Xiaohong Liang, Bin Yang, Guili Ning, Ching-Yu Cheng, Paul R. Healey, Ki Ho Park, Linda M. Zangwill, Tin Aung, Kyoko Ohno-Matsui, Jost B. Jonas, Robert N. Weinreb, Xiulan Zhang, Yizhi Liu, Lin Lv, David Friedman, Kai Gao, Bingqian Liu, Neil M. Bressler, Mingguang He, Xiang Chen, Guangxian Tang |
| Summary: | Purpose - To develop a classification system of visual field (VF) abnormalities in highly myopic eyes with and without glaucoma. - Design - Secondary analysis of VF data from a longitudinal cohort study. - Participants - One thousand eight hundred ninety-three VF tests from 1302 eyes (825 individuals). - Methods - All participants underwent VF testing (Humphrey 24-2 Swedish interactive threshold algorithm standard program; Carl Zeiss Meditec) and detailed ophthalmic examination. A comprehensive set of VF defect patterns was defined via observation of the 1893 VF reports, literature review, and consensus meetings. The classification system comprised 4 major types of VF patterns, including normal type, glaucoma-like defects (paracentral defect, nasal step, partial arcuate defect, arcuate defect), high myopia-related defects (enlarged blind spot, vertical step, partial peripheral rim, nonspecific defect), and combined defects (nasal step with enlarged blind spot). A subset (n = 1000) of the VFs was used to evaluate the interobserver and intraobserver agreement and weighted κ values of the classification system by 2 trained readers. The prevalence of various VF patterns and their associated factors were determined. - Main Outcome Measures - The classification of VF in highly myopic eyes and its associated risk factors. - Results - We found that normal type, glaucoma-like defects, high myopia-related defects, and combined defects accounted for 74.1%, 10.8%, 15.0%, and 0.1% of all unique VF tests, respectively. The interobserver and intraobserver agreements were > 89%, and the corresponding κ values were 0.86 or more between readers. Both glaucoma-like and high myopia-related VF defects were associated with older age (odds ratios [ORs], 1.07 [95% confidence interval (CI), 1.04-1.10; P < 0.001] and 1.06 [95% CI, 1.04-1.10; P < 0.001]) and longer axial length (ORs, 1.65 [95% CI, 1.32-2.07; P < 0.001] and 1.37 [95% CI, 1.11-1.68; P = 0.003]). Longer axial length showed a stronger effect on the prevalence of glaucoma-like VF defects than on the prevalence of high myopia-related VF defects (P = 0.036). - Conclusions - We propose a new and reproducible classification system of VF abnormalities for nonpathologic high myopia. Applying a comprehensive classification system will facilitate communication and comparison of findings among studies. |
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| Item Description: | Online verfügbar: 12 March 2022, Artikelversion: 20 June 2022 Gesehen am 05.12.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1549-4713 |
| DOI: | 10.1016/j.ophtha.2022.03.001 |