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Carbon ion radiotherapy: an evidence-based review and summary recommendations of clinical outcomes for skull-base chordomas and chondrosarcomas

Skull-base chordoma and chondrosarcoma are rare radioresistant tumors treated with surgical resection and/or radiotherapy. Because of the established dosimetric and biological benefits of heavy particle therapy, we performed a systematic and evidence-based review of the clinical outcomes of patients...

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Main Authors: Holtzman, Adam (Author) , Seidensaal, Katharina (Author) , Iannalfi, Alberto (Author) , Kim, Kyung Hwan (Author) , Koto, Masashi (Author) , Yang, Wan-Chin (Author) , Shiau, Cheng-Ying (Author) , Mahajan, Anita (Author) , Ahmed, Safia K. (Author) , Trifiletti, Daniel M. (Author) , Peterson, Jennifer L. (Author) , Koffler, Daniel M. (Author) , Vallow, Laura A. (Author) , Hoppe, Bradford S. (Author) , Rutenberg, Michael S. (Author)
Format: Article (Journal)
Language:English
Published: 17 October 2023
In: Cancers
Year: 2023, Volume: 15, Issue: 20, Pages: 1-12
ISSN:2072-6694
DOI:10.3390/cancers15205021
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers15205021
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/15/20/5021
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Author Notes:Adam L. Holtzman, Katharina Seidensaal, Alberto Iannalfi, Kyung Hwan Kim, Masashi Koto, Wan-Chin Yang, Cheng-Ying Shiau, Anita Mahajan, Safia K. Ahmed, Daniel M. Trifiletti, Jennifer L. Peterson, Daniel M. Koffler, Laura A. Vallow, Bradford S. Hoppe and Michael S. Rutenberg
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Summary:Skull-base chordoma and chondrosarcoma are rare radioresistant tumors treated with surgical resection and/or radiotherapy. Because of the established dosimetric and biological benefits of heavy particle therapy, we performed a systematic and evidence-based review of the clinical outcomes of patients with skull-base chordoma and chondrosarcoma treated with carbon ion radiotherapy (CIRT). A literature review was performed using a MEDLINE search of all articles to date. We identified 227 studies as appropriate for review, and 24 were ultimately included. The published data illustrate that CIRT provides benchmark disease control outcomes for skull-base chordoma and chondrosarcoma, respectively, with acceptable toxicity. CIRT is an advanced treatment technique that may provide not only dosimetric benefits over conventional photon therapy but also biologic intensification to overcome mechanisms of radioresistance. Ongoing research is needed to define the magnitude of benefit, patient selection, and cost-effectiveness of CIRT compared to other forms of radiotherapy.
Item Description:Gesehen am 06.12.2023
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers15205021

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