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Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years

In order to utilize polygenic risk scores (PRSs) for Alzheimer’s disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such as APOE e4 (APOE4) genotype as well as associations to dementia-related biomarkers should be explored. Therefore, we examined t...

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Main Authors: Stocker, Hannah (Author) , Trares, Kira (Author) , Beyer, Léon (Author) , Perna, Laura (Author) , Rujescu, Dan (Author) , Holleczek, Bernd (Author) , Beyreuther, Konrad (Author) , Gerwert, Klaus (Author) , Schöttker, Ben (Author) , Brenner, Hermann (Author)
Format: Article (Journal)
Language:English
Published: 29 July 2023
In: Alzheimer's research & therapy
Year: 2023, Volume: 15, Pages: 1-9
ISSN:1758-9193
DOI:10.1186/s13195-023-01277-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13195-023-01277-8
Verlag, kostenfrei, Volltext: https://alzres.biomedcentral.com/articles/10.1186/s13195-023-01277-8
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Author Notes:Hannah Stocker, Kira Trares, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schöttker and Hermann Brenner
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Summary:In order to utilize polygenic risk scores (PRSs) for Alzheimer’s disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such as APOE e4 (APOE4) genotype as well as associations to dementia-related biomarkers should be explored. Therefore, we examined the association of APOE4 and various PRSs, based on training sets that utilized differing AD definitions, with incident AD and all-cause dementia (ACD) within 17 years, and with levels of phosphorylated tau181 (P-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) in blood. Secondarily, effect modification by APOE4 status and sex was examined.
Item Description:Gesehen am 07.12.2023
Physical Description:Online Resource
ISSN:1758-9193
DOI:10.1186/s13195-023-01277-8

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