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A 3-dimensional histology computer model of malignant melanoma and its implications for digital pathology

Historically, cancer diagnoses have been made by pathologists using two-dimensional histological slides. However, with the advent of digital pathology and artificial intelligence, slides are being digitised, providing new opportunities to integrate their information. Since nature is 3-dimensional (3...

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Main Authors: Kurz, Alexander (Author) , Krahl, Dieter (Author) , Kutzner, Heinz (Author) , Barnhill, Raymond (Author) , Perasole, Antonio (Author) , Figueras, Maria Teresa Fernandez (Author) , Ferrara, Gerardo (Author) , Braun, Stephan A. (Author) , Starz, Hans (Author) , Llamas-Velasco, Mar (Author) , Utikal, Jochen (Author) , Fröhling, Stefan (Author) , Kalle, Christof von (Author) , Kather, Jakob Nikolas (Author) , Schneider, Lucas (Author) , Brinker, Titus Josef (Author)
Format: Article (Journal)
Language:English
Published: November 2023
In: European journal of cancer
Year: 2023, Volume: 193, Pages: 1-7
ISSN:1879-0852
DOI:10.1016/j.ejca.2023.113294
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ejca.2023.113294
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0959804923003969
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Author Notes:Alexander Kurz, Dieter Krahl, Heinz Kutzner, Raymond Barnhill, Antonio Perasole, Maria Teresa Fernandez Figueras, Gerardo Ferrara, Stephan A. Braun, Hans Starz, Mar Llamas-Velasco, Jochen Sven Utikal, Stefan Fröhling, Christof von Kalle, Jakob Nikolas Kather, Lucas Schneider, Titus J. Brinker
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Summary:Historically, cancer diagnoses have been made by pathologists using two-dimensional histological slides. However, with the advent of digital pathology and artificial intelligence, slides are being digitised, providing new opportunities to integrate their information. Since nature is 3-dimensional (3D), it seems intuitive to digitally reassemble the 3D structure for diagnosis. Objective: To develop the first human-3D-melanoma-histology-model with full data and code availability. Further, to evaluate the 3D-simulation together with experienced pathologists in the field and discuss the implications of digital 3D-models for the future of digital pathology.
Item Description:Online verfügbar: 18. August 2023, Artikelversion: 9. September 2023
Gesehen am 08.12.2023
Physical Description:Online Resource
ISSN:1879-0852
DOI:10.1016/j.ejca.2023.113294

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