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The potential and emerging role of quantitative imaging biomarkers for cancer characterization

Similar to the transformation towards personalized oncology treatment, emerging techniques for evaluating oncologic imaging are fostering a transition from traditional response assessment towards more comprehensive cancer characterization via imaging. This development can be seen as key to the achie...

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Main Authors: Tharmaseelan, Hishan (Author) , Hertel, Alexander (Author) , Singer, Shereen (Author) , Nörenberg, Dominik (Author) , Haselmann, Verena (Author) , Schönberg, Stefan (Author) , Froelich, Matthias F. (Author)
Format: Article (Journal)
Language:English
Published: 9 July 2022
In: Cancers
Year: 2022, Volume: 14, Issue: 14, Pages: 1-15
ISSN:2072-6694
DOI:10.3390/cancers14143349
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers14143349
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/14/14/3349
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Author Notes:Hishan Tharmaseelan, Alexander Hertel, Shereen Rennebaum, Dominik Nörenberg, Verena Haselmann, Stefan O. Schoenberg and Matthias F. Froelich
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Summary:Similar to the transformation towards personalized oncology treatment, emerging techniques for evaluating oncologic imaging are fostering a transition from traditional response assessment towards more comprehensive cancer characterization via imaging. This development can be seen as key to the achievement of truly personalized and optimized cancer diagnosis and treatment. This review gives a methodological introduction for clinicians interested in the potential of quantitative imaging biomarkers, treating of radiomics models, texture visualization, convolutional neural networks and automated segmentation, in particular. Based on an introduction to these methods, clinical evidence for the corresponding imaging biomarkers—(i) dignity and etiology assessment; (ii) tumoral heterogeneity; (iii) aggressiveness and response; and (iv) targeting for biopsy and therapy—is summarized. Further requirements for the clinical implementation of these imaging biomarkers and the synergistic potential of personalized molecular cancer diagnostics and liquid profiling are discussed.
Item Description:Dieser Artikel gehört zur Collection: Imaging biomarker in oncology
Gesehen am 19.12.2023
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers14143349

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